Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

被引：1248

作者：

Thanh Chung Pham ^{[1
]}

Van-Nghia Nguyen ^{[2
]}

Choi, Yeonghwan ^{[1
]}

Lee, Songyi ^{[1
,3
]}

Yoon, Juyoung ^{[2
]}

机构：

[1] Pukyong Natl Univ, Ind Convergence Bion Engn 4 0, Busan 48513, South Korea

[2] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea

[3] Pukyong Natl Univ, Dept Chem, Busan 48513, South Korea

来源：

CHEMICAL REVIEWS | 2021年 / 121卷 / 21期

基金：

新加坡国家研究基金会;

关键词：

AGGREGATION-INDUCED-EMISSION; SINGLET OXYGEN GENERATION; TRIPLET EXCITED-STATE; RUTHENIUM(II) POLYPYRIDYL COMPLEXES; CYCLOMETALATED IRIDIUM(III) COMPLEXES; TRANSITION-METAL-COMPLEXES; ATOM-FREE PHOTOSENSITIZERS; RESONANCE ENERGY-TRANSFER; HUMAN SERUM-ALBUMIN; PHTHALOCYANINE-BASED PHOTOSENSITIZER;

D O I：

10.1021/acs.chemrev.1c00381

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the use of light combined with a light-activated chemical, referred to as a PS. Attractively, PDT is one of the alternatives to conventional cancer treatment due to its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although the concept of photosensitizer-based photodynamic therapy has been widely adopted for clinical trials and bioimaging, until now, to our surprise, there has been no relevant review article on rational designs of organic PSs for PDT. Furthermore, most of published review articles in PDT focused on nanomaterials and nanotechnology based on traditional PSs. Therefore, this review aimed at reporting recent strategies to develop innovative organic photosensitizers for enhanced photodynamic therapy, with each example described in detail instead of providing only a general overview, as is typically done in previous reviews of PDT, to provide intuitive, vivid, and specific insights to the readers.

引用

页码：13454 / 13619

页数：166

共 1199 条

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Abolhoda A, 1999, CLIN CANCER RES, V5, P3352

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