[1] Univ Heidelberg Hosp, D-69120 Heidelberg, Germany
[2] Univ Klinikum Heidelberg, Thoraxklin, Ctr Pulm Hypertens, Heidelberg, Germany
[3] Royal Hallamshire Hosp, Pulm Vasc Dis Unit, Sheffield S10 2JF, S Yorkshire, England
[4] Royal Hallamshire Hosp, NIHR, Cardiovasc Biomed Res Unit, Sheffield S10 2JF, S Yorkshire, England
[5] Univ Edinburgh, Edinburgh, Midlothian, Scotland
[6] Univ Sheffield, Royal Hallamshire Hosp, Sheffield S10 2JF, S Yorkshire, England