Role of gut microbiota in liver disease

被引：105

作者：

Albhaisi, Somaya A. M. ^{[1
]}

Bajaj, Jasmohan S. ^{[2
,3
]}

Sanyal, Arun J. ^{[2
]}

机构：

[1] Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA USA

[2] Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA

[3] McGuire Vet Affairs Med Ctr, Richmond, VA USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2020年 / 318卷 / 01期

关键词：

alcoholic hepatitis; bacteria; cirrhosis; gut microbiota; hepatocellular cancer; intestinal microbiome; metagenomics; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; PRIMARY SCLEROSING CHOLANGITIS; INCREASED INTESTINAL PERMEABILITY; BILE-ACIDS; NONALCOHOLIC STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA; BACTERIAL TRANSLOCATION; AUTOIMMUNE HEPATITIS; CIRRHOSIS; ENDOTOXEMIA; DYSBIOSIS;

D O I：

10.1152/ajpgi.00118.2019

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The gut microbiome is the natural intestinal inhabitant that has been recognized recently as a major player in the maintenance of human health and the pathophysiology of many diseases. Those commensals produce metabolites that have various effects on host biological functions. Therefore, alterations in the normal composition or diversity of microbiome have been implicated in various diseases, including liver cirrhosis and nonalcoholic fatty liver disease. Moreover, accumulating evidence suggests that progression of dysbiosis can be associated with worsening of liver disease. Here, we review the possible roles for gut microbiota in the development, progression, and complication of liver disease.

引用

页码：G84 / G98

页数：15

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