Chromosome aberration test of Pigment Yellow 34 (lead chromate) in Chinese hamster ovary cells

被引：2

作者：

Nestmann, Earle R.

Zhang, Baowei

机构：

[1] Cantox Hlth Sci Int, Mississauga, ON L5N 2X7, Canada

[2] Nucro Techn, Scarborough, ON M1H 2W4, Canada

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2007年 / 633卷 / 02期

关键词：

Pigment Yellow 34; lead chromate; genotoxicity; clastogenicity; particle size; solubility;

D O I：

10.1016/j.mrgentox.2007.05.012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lead chromate pigment in the form of the commercial pigment, Pigment Yellow 34, CAS No. 1344-37-2, used in the plastics and coatings industries, did not induce chromosome aberrations in Chinese hamster ovary (CHO) cell line WB(L). Lead chromate pigment is essentially insoluble in water, and in an effort to test the material under realistic conditions, no attempt to solubilize the pigment was made. These results are significant because others have reported lead chromate to cause genotoxicity in various assays, but only under conditions in which its aqueous solubility was artificially enhanced. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：126 / 132

页数：7