Prenatal hypoxia and placental oxidative stress: linkages to developmental origins of cardiovascular disease

被引：55

作者：

Aljunaidy, Mais M. ^{[1
,2
,3
,4
]}

Morton, Jude S. ^{[1
,3
,4
]}

Cooke, Christy-Lynn M. ^{[1
,3
,4
]}

Davidge, Sandra T. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Alberta, Dept Obstet & Gynecol, Edmonton, AB, Canada

[2] Univ Alberta, Dept Physiol, Edmonton, AB, Canada

[3] Women & Childrens Hlth Res Inst, Edmonton, AB, Canada

[4] Cardiovasc Res Ctr, Edmonton, AB, Canada

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | 2017年 / 313卷 / 04期

基金：

加拿大健康研究院;

关键词：

hypoxia; oxidative stress; placenta; DOHaD; cardiovascular disease; RESVERATROL SUPPLEMENTATION; VASCULAR DYSFUNCTION; HYPERTENSION; PREVENTS; MITOCHONDRIAL; ANTIOXIDANT; PREGNANCY; DELIVERY; GROWTH; MECHANISMS;

D O I：

10.1152/ajpregu.00245.2017

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Intrauterine growth restriction (IUGR, a pregnancy complication where the fetus does not reach its genetic growth potential) is a leading cause of fetal morbidity and mortality with a significant impact on population health. IUGR is associated with gestational hypoxia; which can lead to placental oxidative stress and fetal programming of cardiovascular disease. Mitochondria are a major source of placental oxidative stress and may provide a therapeutic target to mitigate the detrimental effects of placental oxidative stress on pregnancy outcomes. A nanoparticle-mediated delivery of a mitochondrial antioxidant to the placenta is a potential novel approach that may avoid unwanted off-target effects on the developing offspring.

引用

页码：R395 / R399

页数：5

共 32 条

[1] Fetal Programming and Cardiovascular Pathology [J].

Alexander, Barbara T. ;

Dasinger, John Henry ;

Intapad, Suttira .

COMPREHENSIVE PHYSIOLOGY, 2015, 5 (02) :997-1025

[2]

Aljunaidy MM, 2017, FASEB J, V31

[3]

[Anonymous], 2004, LOW BIRTHW COUNTR RE

[4] A parallel increase in placental oxidative stress and antioxidant defenses occurs in pre-gestational type 1 but not gestational diabetes [J].

Araujo, J. R. ;

Ramalho, C. ;

Correia-Branco, A. ;

Faria, A. ;

Ferraz, T. ;

Keating, E. ;

Martel, F. .

PLACENTA, 2013, 34 (11) :1095-1098

[5] Mitochondrial - Endoplasmic reticulum interactions in the trophoblast: Stress and senescence [J].

Burton, G. J. ;

Yung, H. W. ;

Murray, A. J. .

PLACENTA, 2017, 52 :146-155

[6] Placental Endoplasmic Reticulum Stress and Oxidative Stress in the Pathophysiology of Unexplained Intrauterine Growth Restriction and Early Onset Preeclampsia [J].

Burton, G. J. ;

Yung, H. -W. ;

Cindrova-Davies, T. ;

Charnock-Jones, D. S. .

PLACENTA, 2009, 30 :S43-S48

[7] Antenatal antioxidant prevents adult hypertension, vascular dysfunction, and microvascular rarefaction associated with in utero exposure to a low-protein diet [J].

Cambonie, Gilles ;

Comte, Blandine ;

Yzydorczyk, Catherine ;

Ntimbane, Thierry ;

Germain, Nathalie ;

Le, Ngoc Loan Oanh ;

Pladys, Patrick ;

Gauthier, Cindy ;

Lahaie, Isabelle ;

Abran, Daniel ;

Lavoie, Jean-Claude ;

Nuyt, Anne Monique .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2007, 292 (03) :R1236-R1245

[8] Perinatal Resveratrol Supplementation to Spontaneously Hypertensive Rat Dams Mitigates the Development of Hypertension in Adult Offspring [J].

Care, Alison S. ;

Sung, Miranda M. ;

Panahi, Sareh ;

Gragasin, Ferrante S. ;

Dyck, Jason R. B. ;

Davidge, Sandra T. ;

Bourque, Stephane L. .

HYPERTENSION, 2016, 67 (05) :1038-1044

[9] Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions [J].

Curtis, Daniel J. ;

Sood, Aman ;

Phillips, Tom J. ;

Leinster, Veronica H. L. ;

Nishiguchi, Akihiro ;

Coyle, Christopher ;

Lacharme-Lora, Lizeth ;

Beaumont, Oliver ;

Kemp, Helena ;

Goodall, Roberta ;

Cornes, Leila ;

Giugliano, Michele ;

Barone, Rocco A. ;

Matsusaki, Michiya ;

Akashi, Mitsuru ;

Tanaka, Hiroyoshi Y. ;

Kano, Mitsunobu ;

McGarvey, Jennifer ;

Halemani, Nagaraj D. ;

Simon, Katja ;

Keehan, Robert ;

Ind, William ;

Masters, Tracey ;

Grant, Simon ;

Athwal, Sharan ;

Collett, Gavin ;

Tannetta, Dionne ;

Sargent, Ian L. ;

Scull-Brown, Emma ;

Liu, Xun ;

Aquilina, Kristian ;

Cohen, Nicki ;

Lane, Jon D. ;

Thoresen, Marianne ;

Hanley, Jon ;

Randall, Andrew ;

Case, C. Patrick .

EXPERIMENTAL NEUROLOGY, 2014, 261 :386-395

[10] Micronutrient prenatal supplementation prevents the development of hypertension and vascular endothelial damage induced by intrauterine malnutrition [J].

Franco, Maria do Carmo ;

Ponzio, Beatriz Felice ;

Gomes, Guiomar Nascimento ;

Gil, Frida Zaladek ;

Tostes, Rita ;

Catelli Carvalho, Maria Helena ;

Fortes, Zuleica Bruno .

LIFE SCIENCES, 2009, 85 (7-8) :327-333

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