Synthesis and evaluation of novel O2-derived diazeniumdiolates as photochemical and real-time monitoring nitric oxide delivery agents

被引：18

作者：

Luo, Xiaojun ^{[1
]}

Wu, Jianbing ^{[1
]}

Lv, Tian ^{[1
]}

Lai, Yisheng ^{[1
]}

Zhang, Honghua ^{[2
]}

Lu, Jin-Jian ^{[3
]}

Zhang, Yihua ^{[1
]}

Huang, Zhangjian ^{[1
]}

机构：

[1] China Pharmaceut Univ, State Key Lab Nat Med, Jiangsu Key Lab Drug Discovery Metab Dis, Jiangsu Key Lab Drug Screening, Nanjing 210009, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Foreign Languages Dept, Nanjing 210009, Jiangsu, Peoples R China

[3] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 12期

基金：

中国国家自然科学基金;

关键词：

P-HYDROXYPHENACYL; RELEASE; DONORS; NO; DERIVATIVES; PROGRESSION; NONOATES;

D O I：

10.1039/c7qo00695k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A group of photochemical nitric oxide (NO) delivery agents, O-2-(4-hydroxyphenacyl) diazeniumdiolates 1-2 as well as O-2-(3-(benzothiazole-2-yl)-4-hydroxyphenacyl) diazeniumdiolates 3-4, could be triggered by ultraviolet light (365-400 nm) and visible light (>= 410 nm), respectively, to produce NO in cancer cells and generate potent antitumor activity. Importantly, with the photolysis of 3 being initiated, the accompanying distinct fluorescence color change (from green to blue) may act as a qualitative real-time optical indicator for NO release in cancer cells.

引用

页码：2445 / 2449

页数：5

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