Epigallocatechin-3-gallate Regulates NADPH Oxidase Expression in Human Umbilical Vein Endothelial Cells

被引：25
作者：
Ahn, Hee Yul [1 ]
Kim, Chan Hyung [1 ]
Ha, Tae-Sun [2 ]
机构：
[1] Chungbuk Univ, Coll Med, Dept Pharmacol, Cheongju 361763, South Korea
[2] Chungbuk Univ, Coll Med, Dept Pediat, Cheongju 361763, South Korea
来源：
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | 2010年 / 14卷 / 05期
关键词：
EGCG; NADPH oxidase; Angiotensin II; ROS; HUVEC; ANGIOTENSIN-II; OXIDATIVE STRESS; NAD(P)H OXIDASE; GENE-EXPRESSION; GREEN TEA; SUPEROXIDE; ACTIVATION; FLAVONOIDS; ADHESION; NOX4;
D O I：
10.4196/kjpp.2010.14.5.325
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Vascular NADPH oxidase plays a pivotal role in producing superoxide in endothelial cells and thus acts in the initiation and development of inflammatory cardiovascular diseases such as atherosclerosis Epigallocatechin-3-gallate (EGCG), the major catechin derived from green tea, has multiple beneficial effects for treating cardiovascular disease but the effect of EGCG on the expression of vascular NADPH oxidase remains unknown In this study, we investigated the mechanism(s) by which EGCG might inhibit the expression of subunits of NADPH oxidase, namely p47(phox), p67(phox) and p22(phox), induced by angiotensin II (Ang II) in human umbilical vein endothelial cells Ang II increased the expression levels of p47(phox), p67(phox), and p22(phox), but EGCG counteracted this effect on p47(phox) Moreover, EGCG did not affect the production of reactive oxygen species induced by Ang II These data suggest a novel mechanism whereby EGCG might provide direct vascular benefits for treating inflammatory cardiovascular diseases
引用
收藏
页码：325 / 329
页数：5
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