Cyclooxygenases as the principal targets for the actions of NSAIDS

被引：36

作者：

Smith, TJ

机构：

[1] Albany Med Coll, Div Mol & Cellular Med A 175, Dept Med, Albany, NY 12208 USA

[2] Samuel S Stratton Vet Affairs Med Ctr, Albany, NY USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 1998年 / 24卷 / 03期

关键词：

D O I：

10.1016/S0889-857X(05)70023-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The recent identification, cloning, and characterization of two cyclooxygenases has provided insight into how nonsteroidal anti-inflammatory drugs can beneficially inhibit prostaglandin production in inflammation but also produce side-effects in the gut and kidney. The subtle differences in the sites in which these drugs bind the enzymes has allowed development of inhibitors that exhibit selectivity for the inflammatory cyclooxygenase and spare the housekeeping enzyme. This selectivity in theory should enhance the therapeutic potential of these new drugs.

引用

页码：501 / +

页数：24

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