ANTHELMINTIC DRUG DISCOVERY: INTO THE FUTURE

被引：81
作者：
Geary, Timothy G. [1 ]
Sakanari, Judy A. [1 ]
Caffrey, Conor R. [1 ]
机构：
[1] McGill Univ, Inst Parasitol, Quebec City, PQ H9X 3V9, Canada
来源：
JOURNAL OF PARASITOLOGY | 2015年 / 101卷 / 02期
关键词：
SCHISTOSOMA-MANSONI INVITRO; ON-A-CHIP; HIGH-THROUGHPUT; ECHINOCOCCUS-MULTILOCULARIS; ANTIPARASITIC DRUGS; RESISTANCE; BRUGIA; CULTIVATION; WHOLE; 3RD-STAGE;
D O I：
10.1645/14-703.1
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The last half-century has provided all of the (few) drugs currently used to treat human helminthiases. Concern regarding the long-term utility of these drugs, given how readily resistance evolves in the veterinary-agricultural sector, spurs the discovery of new chemical entities. We review the approaches and technologies in use to identify anthelmintics and discuss a number of drug discovery paradigms that may prove pivotal to the next half-century of anthelmintic development.
引用
收藏
页码：125 / 133
页数：9
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