ANTHELMINTIC DRUG DISCOVERY: INTO THE FUTURE

被引：81

作者：

Geary, Timothy G. ^{[1
]}

Sakanari, Judy A. ^{[1
]}

Caffrey, Conor R. ^{[1
]}

机构：

[1] McGill Univ, Inst Parasitol, Quebec City, PQ H9X 3V9, Canada

来源：

JOURNAL OF PARASITOLOGY | 2015年 / 101卷 / 02期

关键词：

SCHISTOSOMA-MANSONI INVITRO; ON-A-CHIP; HIGH-THROUGHPUT; ECHINOCOCCUS-MULTILOCULARIS; ANTIPARASITIC DRUGS; RESISTANCE; BRUGIA; CULTIVATION; WHOLE; 3RD-STAGE;

D O I：

10.1645/14-703.1

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The last half-century has provided all of the (few) drugs currently used to treat human helminthiases. Concern regarding the long-term utility of these drugs, given how readily resistance evolves in the veterinary-agricultural sector, spurs the discovery of new chemical entities. We review the approaches and technologies in use to identify anthelmintics and discuss a number of drug discovery paradigms that may prove pivotal to the next half-century of anthelmintic development.

引用

页码：125 / 133

页数：9

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