Oxphos Inhibition Induces Formation of Tunneling Nanotubes in AML Cells and Facilitates Mitochondrial Transfer from BM Stroma to AML That Contributes to Microenvironment-Mediated Drug-Resistance of AML

被引：1

作者：

Yang, Haeun ^{[1
,2
]}

Tabe, Yoko ^{[1
,3
,4
]}

Saito, Kaori ^{[1
]}

Yamatani, Kotoko ^{[1
]}

Jacamo, Rodrigo ^{[3
]}

Ma, Helen ^{[5
]}

Ruvolo, Vivian ^{[3
]}

Zhang, Qi ^{[5
]}

Kuruvilla, Vinitha Mary ^{[5
]}

Baran, Natalia ^{[6
]}

Imoto, Junichi ^{[7
]}

Ikeo, Kazuho ^{[8
]}

Moriya, Kaori ^{[9
]}

Murakami-Tonami, Yuko ^{[1
]}

Suzuki, Koya ^{[1
,10
]}

Miida, Takashi ^{[1
]}

Andreeff, Michael ^{[3
]}

Vellano, Christopher P. ^{[11
]}

Marszalek, Joseph ^{[12
]}

Konopleva, Marina Y. ^{[6
]}

机构：

[1] Juntendo Univ, Grad Sch Med, Dept Clin Lab Med, Tokyo, Japan

[2] Juntendo Univ, Grad Sch Med, Leading Ctr Dev & Res Canc Med, Tokyo, Japan

[3] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Sect Mol Hematol & Therapy, Houston, TX 77030 USA

[4] Juntendo Univ, Grad Sch Med, Dept Next Generat Hematol Lab Med, Tokyo, Japan

[5] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

[6] MD Anderson Canc Ctr, Dept Leukemia, Houston, TX USA

[7] Natl Inst Genet, Shizuoka, Japan

[8] Natl Inst Genet, Ctr Informat Biol, Shizuoka, Japan

[9] Juntendo Univ, Grad Sch Med, Lab Morphol & Image Anal, Tokyo, Japan

[10] Juntendo Univ, Res Inst Dis Old Age, Grad Sch Med, Tokyo, Japan

[11] Univ Texas MD Anderson Canc Ctr, TRACTION, Houston, TX 77030 USA

[12] MD Anderson Canc Ctr, Houston, TX USA

来源：

BLOOD | 2019年 / 134卷

关键词：

D O I：

10.1182/blood-2019-125007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

911

引用

页数：4

共 6 条

[1] Mitochondrial Transfer Confers Microenvironment-Mediated Resistance to Oxphos Inhibition in AML
Yang, Haeun
Tabe, Yoko
Saito, Kaori
Jacamo, Rodrigo
Ma, Helen
Ruvolo, Vivian
Imoto, Junichi
Ikeo, Kazuho
Mogushi, Kaoru
Hosoya, Masaki
Yamaguchi, Shigeo
Yamatani, Kotoko
Murakami-Tonami, Yuko
Suzuki, Koya
Miida, Takashi
Andreeff, Michael
Marszalek, Joseph R.
Konopleva, Marina Y.
BLOOD, 2018, 132
[2] NOTCH SIGNALLING INHIBITION AS A MULTI-TARGET THERAPY TO OVERCOME BONE MARROW MICROENVIRONMENT-MEDIATED DRUG RESISTANCE IN AML
Kamga, P. Takam
Bassi, G.
Cassaro, A.
Adamo, A.
Gatti, A.
Dal Collo, G.
Midolo, M.
Carusone, R.
Di Trapani, M.
Bonifacio, M.
Krampera, M.
HAEMATOLOGICA, 2016, 101 : 207 - 208
[3] p53 Activation of Mesenchymal Stromal Cells (MSC) Partially Abrogates Microenvironment-Mediated Resistance to FLT3 Inhibition In FLT3/ITD AML.
Kojima, Kensuke
McQueen, Teresa
Shpall, Elizabeth J.
Wang, Rui-Yu
Andreeff, Michael
BLOOD, 2010, 116 (21) : 888 - 889
[4] Daratumumab Inhibits AML Metabolic Capacity and Tumor Growth through Inhibition of CD38 Mediated Mitochondrial Transfer from Bone Marrow Stromal Cells to Blasts in the Leukemic Microenvironment
Mistry, Jayna J.
Hellmich, Charlotte
Moore, Jamie A.
Marlein, Christopher R.
Pillinger, Genevra
Collins, Angela
Bowles, Kristian M.
Rushworth, Stuart A.
BLOOD, 2019, 134
[5] p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α-mediated down-regulation of CXCL12
Kojima, Kensuke
McQueen, Teresa
Chen, Ye
Jacamo, Rodrigo
Konopleva, Marina
Shinojima, Naoki
Shpall, Elizabeth
Huang, Xuelin
Andreeff, Michael
BLOOD, 2011, 118 (16) : 4431 - 4439
[6] Massive mobilization of AML cells into circulation by disruption of leukemia/stroma cell interactions using CXCR4 antagonist AMD3100: First evidence in patients and potential for abolishing bone marrow microenvironment-mediated resistance.
Andreeff, Michael
Konoplev, Sergej
Wang, Rui-Yu
Zeng, Zhihong
McQueen, Teresa
Shi, Yue-Xi
Medeiros, L. Jeffrey
Estey, Elihu
McCarty, John M.
Elkins, Stephanie
Champlin, Richard
Calandra, Gary
Bridger, Gary
Konopleva, Marina
BLOOD, 2006, 108 (11) : 171A - 171A

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