Histone deacetylase 6 in health and disease

被引：10
|
作者：
Seidel, Carole [1 ]
Schnekenburger, Michael [1 ]
Dicato, Mario [1 ]
Diederich, Marc [2 ]
机构：
[1] Hop Kirchberg, Lab Mol & Cellular Biol Canc, L-2540 Luxembourg, Luxembourg
[2] Seoul Natl Univ, Coll Pharm, Dept Pharm, Seoul 151742, South Korea
来源：
EPIGENOMICS | 2015年 / 7卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
autoimmune response; cancer; epigenetics; HDAC6; inhibitor; histone deacetylase; neurodegenerative disease; HUMAN-IMMUNODEFICIENCY-VIRUS; HEAT-SHOCK-PROTEIN; ALPHA-TUBULIN; PHARMACOKINETIC PROPERTIES; TRANSCRIPTION FACTOR; HDAC6; INHIBITION; STRESS GRANULES; CANCER CELLS; ACETYLATION; EXPRESSION;
D O I：
10.2217/EPI.14.69
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Histone deacetylase (HDAC) 6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including alpha-tubulin and HSP90 alpha, and is involved in protein trafficking and degradation, cell shape and migration. Consequently, deregulation of HDAC6 activity was associated to a variety of diseases including cancer, neurodegenerative diseases and pathological autoimmune response. Therefore, HDAC6 represents an interesting potential therapeutic target. In this review, we discuss structural features of this histone deacetylase, regulation of its expression and activity, biological functions, implication in human disease initiation and progression. Finally will describe novel and selective HDAC6 inhibitors.
引用
收藏
页码：103 / 118
页数：16
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