Synthesis and Antimicrobial Activity of Quinazolin-4(3H)-ones Incorporating Sulfonamido-4-thiazolidinone

被引：3

作者：

Patel, Navin B. ^{[1
]}

Patel, Jaymin C. ^{[1
]}

Patel, Virendra N. ^{[1
]}

机构：

[1] Veer Narmad S Gujarat Univ, Dept Chem, Surat 395007, Gujarat, India

来源：

CHINESE JOURNAL OF CHEMISTRY | 2010年 / 28卷 / 10期

关键词：

biological activity; quinazolin-4(3H)-one; sulfonamide; 4-thiazolidinone; BIOLOGICAL-ACTIVITIES; ANTI-HIV; DERIVATIVES; AGENTS; SULFONAMIDES; ANTICANCER; 2,3-DIARYL-1,3-THIAZOLIDIN-4-ONES; DESIGN;

D O I：

10.1002/cjoc.201090332

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Some new derivatives 7-chloro-2-[2-(2,6-dichlorophenyl)amino]benzyl-3-[4-(2-substituted phenyl-4-oxo-thiazolidin-3-yl)phenyl]sulfonamido-quinazolin-4(3H)-ones 5a-5l were synthesized from 2-[2-(2,6-dichlorophenyl)amino]phenyl acetic acid via acid chloride, benzoxazinone, amino quinazolin-4(3H)-one and Schiff base formation. The synthesized compounds were screened for in vitro antibacterial and antifungal activities by broth micro dilution method. Some of the Schiff base as well as 4-thiazolidinone derivatives showed promising antibacterial activity while pronounced antifungal activity was observed against C. albicans.

引用

页码：1989 / 1997

页数：9

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