Synthesis and Antimicrobial Activity of Quinazolin-4(3H)-ones Incorporating Sulfonamido-4-thiazolidinone

Some new derivatives 7-chloro-2-[2-(2,6-dichlorophenyl)amino]benzyl-3-[4-(2-substituted phenyl-4-oxo-thiazolidin-3-yl)phenyl]sulfonamido-quinazolin-4(3H)-ones 5a-5l were synthesized from 2-[2-(2,6-dichlorophenyl)amino]phenyl acetic acid via acid chloride, benzoxazinone, amino quinazolin-4(3H)-one and Schiff base formation. The synthesized compounds were screened for in vitro antibacterial and antifungal activities by broth micro dilution method. Some of the Schiff base as well as 4-thiazolidinone derivatives showed promising antibacterial activity while pronounced antifungal activity was observed against C. albicans.