Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study

被引：55

作者：

Zheng, Ju-Sheng ^{[1
]}

Sharp, Stephen J. ^{[1
]}

Imamura, Fumiaki ^{[1
]}

Koulman, Albert ^{[2
,3
]}

Schulze, Matthias B. ^{[4
]}

Ye, Zheng ^{[1
]}

Griffin, Jules ^{[5
]}

Guevara, Marcela ^{[6
,7
,8
]}

Maria Huerta, Jose ^{[8
,9
]}

Kroeger, Janine ^{[4
]}

Sluijs, Ivonne ^{[10
]}

Agudo, Antonio ^{[11
]}

Barricarte, Aurelio ^{[6
,7
,8
]}

Boeing, Heiner ^{[12
]}

Colorado-Yohar, Sandra ^{[7
,13
]}

Dow, Courtney ^{[14
,15
,16
]}

Dorronsoro, Miren ^{[17
]}

Dinesen, Pia T. ^{[18
]}

Fagherazzi, Guy ^{[14
,15
,16
]}

Franks, Paul W. ^{[19
,20
]}

Feskens, Edith J. M. ^{[21
]}

Kuehn, Tilman ^{[22
]}

Katzke, Verena Andrea ^{[22
]}

Key, Timothy J. ^{[23
]}

Khaw, Kay-Tee ^{[24
]}

de Magistris, Maria Santucci ^{[25
]}

Romana Mancini, Francesca ^{[14
,15
,16
]}

Molina-Portillo, Elena ^{[8
,26
]}

Nilsson, Peter M. ^{[19
]}

Olsen, Anja ^{[27
]}

Overvad, Kim ^{[18
,28
]}

Palli, Domenico ^{[29
]}

Ramon Quiros, Jose ^{[30
]}

Rolandsson, Olov ^{[20
]}

Ricceri, Fulvio ^{[31
,32
]}

Spijkerman, Annemieke M. W. ^{[33
]}

Slimani, Nadia ^{[34
]}

Tagliabue, Giovanna ^{[35
]}

Tjonneland, Anne ^{[27
]}

Tumino, Rosario ^{[36
]}

van der Schouw, Yvonne T. ^{[10
]}

Langenberg, Claudia ^{[1
]}

Riboli, Elio ^{[37
]}

Forouhi, Nita G. ^{[1
]}

Wareham, Nicholas J. ^{[1
]}

机构：

[1] Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Box 285,Cambridge Biomed Campus, Cambridge CB2 0QQ, England

[2] MRC Elsie Widdowson Lab, Cambridge, England

[3] NIHR BRC Nutr Biomarker Lab, Cambridge, England

[4] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[5] Univ Cambridge, Dept Biochem, Cambridge, England

[6] Navarra Publ Hlth Inst ISPN, Pamplona, Spain

[7] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain

[8] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain

[9] Murcia Reg Hlth Council, Dept Epidemiol, IMIB Arrixaca, Murcia, Spain

[10] Univ Med Ctr Utrecht, Utrecht, Netherlands

[11] Hosp Llobregat, Catalan Inst Oncol IDIBELL, Canc Epidemiol Res Program, Unit Nutr & Canc, Barcelona, Spain

[12] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[13] Univ Antioquia, Natl Fac Publ Hlth, Res Grp Demog & Hlth, Medellin, Colombia

[14] Ctr Res Epidemiol & Populat Hlth, INSERM U1018, Villejuif, France

[15] Univ Paris Sud, Univ Paris Saclay, Villejuif, France

[16] Gustave Roussy, F-94805 Villejuif, France

[17] Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[18] Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark

[19] Lund Univ, Malmo, Sweden

[20] Umea Univ, Umea, Sweden

[21] Wageningen Univ, Wageningen, Netherlands

[22] Div Canc Epidemiol, German Canc Res Ctr DKFZ, Heidelberg, Germany

[23] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

[24] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[25] AOU Federico II, Naples, Italy

[26] Univ Granada, Hosp Univ Granada, Inst Invest Biosanitaria ibs GRANADA, Escuela Andaluza Salud Publ, Granada, Spain

[27] Danish Canc Soc Res Ctr, Copenhagen, Denmark

[28] Aarhus Univ, Sect Epidemiol, Dept Publ Hlth, Aarhus, Denmark

[29] Canc Res & Prevent Inst ISPO, Florence, Italy

[30] Publ Hlth Directorate, Asturias, Spain

[31] Univ Turin, Dept Clin & Biol Sci, Turin, Italy

[32] Reg Hlth Serv ASL TO3, Unit Epidemiol, Turin, Italy

[33] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[34] Int Agcy Res Canc, Lyon, France

[35] Ist Nazl Tumori, Fdn IRCCS, Milan, Italy

[36] ASP, Civ MP Arezzo Hosp, Canc Registry & Histopathol Dept, Ragusa, Italy

[37] Imperial Coll London, Sch Publ Hlth, London, England

来源：

BMC MEDICINE | 2017年 / 15卷

基金：

英国医学研究理事会; 瑞典研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

Saturated fatty acids; Odd-chain; Even-chain; Very-long-chain; Metabolic markers; Lipids; Hepatic; Glycaemic; Inflammation; DE-NOVO LIPOGENESIS; SERUM-CHOLESTEROL ESTER; MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; RISK-FACTORS; MILK-FAT; DIETARY; INTERHEART; BIOMARKERS; PALMITATE;

D O I：

10.1186/s12916-017-0968-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. Methods: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested. Results: Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption. Conclusions: Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. The clinical and biochemical implications of these findings may vary by adiposity and alcohol intake.

引用

页数：12

共 46 条

[1] De nova lipogenesis in health and disease [J].

Ameer, Fatima ;

Scandiuzzi, Lisa ;

Hasnain, Shahida ;

Kalbacher, Hubert ;

Zaidi, Nousheen .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2014, 63 (07) :895-902

[2]

Capuzzi D.M., 2007, Clinical Diabetes, V25, P16, DOI [10.2337/diaclin.25.1.16, DOI 10.2337/DIACLIN.25.1.16]

[3] Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk A Systematic Review and Meta-analysis [J].

Chowdhury, Rajiv ;

Warnakula, Samantha ;

Kunutsor, Setor ;

Crowe, Francesca ;

Ward, Heather A. ;

Johnson, Laura ;

Franco, Oscar H. ;

Butterworth, Adam S. ;

Forouhi, Nita G. ;

Thompson, Simon G. ;

Khaw, Kay-Tee ;

Mozaffarian, Dariush ;

Danesh, John ;

Di Angelantonio, Emanuele .

ANNALS OF INTERNAL MEDICINE, 2014, 160 (06) :398-+

[4] Biomarkers of Dairy Fatty Acids and Risk of Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosis [J].

Otto, Marcia C. de Oliveira ;

Nettleton, Jennifer A. ;

Lemaitre, Rozenn N. ;

Steffen, Lyn M. ;

Kromhout, Daan ;

Rich, Stephen S. ;

Tsai, Michael Y. ;

Jacobs, David R., Jr. ;

Mozaffarian, Dariush .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2013, 2 (04) :e000092

[5] Individual saturated fatty acids are associated with different components of insulin resistance and glucose metabolism: the GOCADAN study [J].

Ebbesson, Sven O. E. ;

Tejero, M. Elizabeth ;

Lopez-Alvarenga, Juan Carlos ;

Harris, William S. ;

Ebbesson, Lars O. E. ;

Devereux, Richard B. ;

MacCluer, Jean W. ;

Wenger, Charlotte ;

Laston, Sandra ;

Fabsitz, Richard R. ;

Howard, Barbara V. ;

Comuzzie, Anthony G. .

INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH, 2010, 69 (04) :344-351

[6] Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study [J].

Forouhi, Nita G. ;

Koulman, Albert ;

Sharp, Stephen J. ;

Imamura, Fumiaki ;

Kroger, Janine ;

Schulze, Matthias B. ;

Crowe, Francesca L. ;

Huerta, Jose Maria ;

Guevara, Marcela ;

Beulens, Joline W. J. ;

van Woudenbergh, Geertruida J. ;

Wang, Laura ;

Summerhill, Keith ;

Griffin, Julian L. ;

Feskens, Edith J. M. ;

Amiano, Pilar ;

Boeing, Heiner ;

Clavel-Chapelon, Francoise ;

Dartois, Laureen ;

Fagherazzi, Guy ;

Franks, Paul W. ;

Gonzalez, Carlos ;

Jakobsen, Marianne Uhre ;

Kaaks, Rudolf ;

Key, Timothy J. ;

Khaw, Kay-Tee ;

Kuhn, Tilman ;

Mattiello, Amalia ;

Nilsson, Peter M. ;

Overvad, Kim ;

Pala, Valeria ;

Palli, Domenico ;

Quiros, J. Ramon ;

Rolandsson, Olov ;

Roswall, Nina ;

Sacerdote, Carlotta ;

Sanchez, Mara-Jose ;

Slimani, Nadia ;

Spijkerman, Annemieke M. W. ;

Tjonneland, Anne ;

Tormo, Maria-Jose ;

Tumino, Rosario ;

van der A, Daphne L. ;

van der Schouw, Yvonne T. ;

Langenberg, Claudia ;

Riboli, Elio ;

Wareham, Nicholas J. .

LANCET DIABETES & ENDOCRINOLOGY, 2014, 2 (10) :810-818

[7] Plasma Phospholipid Saturated Fatty Acids and Incident Atrial Fibrillation: The Cardiovascular Health Study [J].

Fretts, Amanda M. ;

Mozaffarian, Dariush ;

Siscovick, David S. ;

Djousse, Luc ;

Heckbert, Susan R. ;

King, Irena B. ;

McKnight, Barbara ;

Sitlani, Colleen ;

Sacks, Frank M. ;

Song, Xiaoling ;

Sotoodehnia, Nona ;

Spiegelman, Donna ;

Wallace, Erin R. ;

Lemaitre, Rozenn N. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2014, 3 (03)

[8]

FRIEDEWALD WT, 1972, CLIN CHEM, V0018

[9] High-density lipoprotein cholesterol and triglycerides as therapeutic targets for preventing and treating coronary artery disease [J].

Gotto, AM .

AMERICAN HEART JOURNAL, 2002, 144 (06) :S33-S42

[10] Chain length-specific properties of ceramides [J].

Groesch, Sabine ;

Schiffmann, Susanne ;

Geisslinger, Gerd .

PROGRESS IN LIPID RESEARCH, 2012, 51 (01) :50-62

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