Targeting KDM5 Demethylases: Inhibition and Degradation

被引：6
|
作者：
Fu, Xiaoli [1 ]
Yang, Chao [2 ]
Yu, Bin [3 ]
机构：
[1] Zhengzhou Univ, Coll Publ Heath, Zhengzhou 450001, Peoples R China
[2] Zhejiang Ocean Univ, Inst Innovat & Applicat, Zhoushan 316022, Zhejiang, Peoples R China
[3] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2020年 / 20卷 / 04期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
FAMILY;
D O I：
10.2174/156802662004200304124340
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：261 / 263
页数：3
相关论文
共 50 条
  • [21] Inhibition of KDM5 Attenuates Renal Fibrosis After Ischemic Kidney Injury
    Jo, Wonji
    Park, Junkyu
    Koh, Eun Sil
    Chung, Sungjin
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022, 33 (11): : 626 - 626
  • [22] Identification of potent, selective KDM5 inhibitors
    Gehling, Victor S.
    Bellon, Steven F.
    Harmange, Jean-Christophe
    LeBlanc, Yves
    Poy, Florence
    Odate, Shobu
    Buker, Shane
    Lan, Fei
    Arora, Shilpi
    Williamson, Kaylyn E.
    Sandy, Peter
    Cummings, Richard T.
    Bailey, Christopher M.
    Bergeron, Louise
    Mao, Weifeng
    Gustafson, Amy
    Liu, Yichin
    VanderPorten, Erica
    Audia, James E.
    Trojer, Patrick
    Albrecht, Brian K.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (17) : 4350 - 4354
  • [23] Solving the puzzle of fibrosis resolution in alcohol-associated liver disease: An insight from KDM5 demethylases and LXR activation
    Ma, Jing
    Liangpunsakul, Suthat
    HEPATOLOGY, 2024, 80 (01) : 14 - 17
  • [24] At Long Last Potent and Selective KDM5 Inhibitors
    Rotili, Dante
    Mattevi, Andrea
    CELL CHEMICAL BIOLOGY, 2016, 23 (07): : 749 - 751
  • [25] Development of KDM5 covalent inhibitors as chemical probes
    Vazquez-Rodriguez, Saleta
    Wright, Miranda
    Brennan, Paul
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
  • [26] (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive tumorigenesis in IDH-mutant cancers.
    Gunn, Kathryn E.
    Myllykoski, Matti
    Cao, John
    Huang, Bofu
    Rouaisnel, Betty
    Diplas, Bill
    Levitt, Michael M.
    Looper, Ryan
    Doench, John G.
    Ligon, Keith L.
    Kornblum, Harley I.
    Yan, Hai
    McBrayer, Samuel
    Godley, Lucy A.
    Koivunen, Peppi
    Losman, Julie-Aurore
    CANCER RESEARCH, 2022, 82 (12)
  • [27] Design, Synthesis and Characterization of Covalent KDM5 Inhibitors
    Vazquez-Rodriguez, Saleta
    Wright, Miranda
    Rogers, Catherine M.
    Cribbs, Adam P.
    Velupillai, Srikannathasan
    Philpott, Martin
    Lee, Henry
    Dunford, James E.
    Huber, Kilian V. M.
    Robers, Matthew B.
    Vasta, James D.
    Thezenas, Marie-Laetitia
    Bonham, Sarah
    Kessler, Benedikt
    Bennett, James
    Fedorov, Oleg
    Raynaud, Florence
    Donovan, Adam
    Blagg, Julian
    Bavetsias, Vassilios
    Oppermann, Udo
    Bountra, Chas
    Kawamura, Akane
    Brennan, Paul E.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 58 (02) : 515 - 519
  • [28] (R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers br
    Gunn, Kathryn
    Myllykoski, Matti
    Cao, John Z.
    Ahmed, Manna
    Huang, Bofu
    Rouaisnel, Betty
    Diplass, Bill H.
    Levitt, Michael M.
    Looper, Ryan
    Doench, John G.
    Ligon, Keith L.
    Kornblum, Harley I.
    McBrayers, Samuel K.
    Yan, Hai
    Duy, Cihangir
    Godley, Lucy A.
    Koivunen, Peppi
    Losman, Julie-Aurore
    CANCER DISCOVERY, 2023, 13 (06) : 1478 - 1497
  • [29] Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B
    Pippa, Simone
    Mannironi, Cecilia
    Licursi, Valerio
    Bombardi, Luca
    Colotti, Gianni
    Cundari, Enrico
    Mollica, Adriano
    Coluccia, Antonio
    Naccarato, Valentina
    La Regina, Giuseppe
    Silvestri, Romano
    Negri, Rodolfo
    MOLECULES, 2019, 24 (09):
  • [30] Characterization of a linked jumonji domain of the KDM5/JARID1 family of histone H3 lysine 4 demethylases
    Horton, John R.
    Engstrom, Amanda
    Zoeller, Elizabeth L.
    Liu, Xu
    Shanks, John R.
    Zhang, Xing
    Johns, Margaret A.
    Vertino, Paula M.
    Fu, Haian
    Cheng, Xiaodong
    Journal of Biological Chemistry, 2016, 291 (06): : 2631 - 2646
12345