Illuminating drug discovery with biological pathways

被引：82
作者：
Apic, G
Ignjatovic, T
Boyer, S
Russell, RB
机构：
[1] Cambridge Cell Networks, Cambridge CB3 0FD, England
[2] AstraZeneca R&D, Safety Assessment, S-43183 Molndal, Sweden
[3] EMBL, D-69112 Heidelberg, Germany
来源：
FEBS LETTERS | 2005年 / 579卷 / 08期
关键词：
systems biology; drug discovery; biological pathways;
D O I：
10.1016/j.febslet.2005.02.023
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Systems biology promises to impact significantly on the drug discovery process. One of its ultimate goals is to provide an understanding of the complete set of molecular mechanisms describing an organism. Although this goal is a long way off, many useful insights can already come from currently available information and technology. One of the biggest challenges in drug discovery today is the high attrition rate: many promising candidates prove ineffective or toxic owing to a poor understanding of the molecular mechanisms of biological systems they target. A "systems" approach can help identify pathways related to a disease and can suggest secondary effects of drugs that might cause these problems and thus ultimately improve the drug discovery pipeline. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1872 / 1877
页数：6
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