Iron-catalyzed C-F bond silylation and borylation of fluoroarenes

被引：15

作者：

Sun, Minghui ^{[1
]}

Tao, Maoling ^{[2
]}

Zhao, Liang ^{[2
]}

Li, Weipiao ^{[2
]}

Liu, Zhengli ^{[1
]}

He, Chun-Yang ^{[2
]}

Feng, Zhang ^{[1
,3
,4
]}

机构：

[1] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China

[2] Zunyi Med Univ, Sch Pharm, Gener Drug Res Ctr Guizhou Prov, Key Lab Biocatalysis & Chiral Drug Synth Guizhou, Zunyi 563003, Guizhou, Peoples R China

[3] North Sichuan Med Coll, Sichuan Key Lab Med Imaging, Nanchong 637000, Sichuan, Peoples R China

[4] North Sichuan Med Coll, Sch Preclin Med, Nanchong 637000, Sichuan, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 19期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

HYDROSILYLATION; ACTIVATION; ALKENE; ALKYL; FUNCTIONALIZATION; POLYFLUOROARENES; GENERATION; COMPLEXES; FLUORINE;

D O I：

10.1039/d1qo00839k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iron-catalyzed functionalization of inert bonds has scarcely been documented. Herein, we report an iron-catalyzed method for the silylation and borylation of (hetero)aromatic fluorides. This protocol features a wide range of substrates, high efficiency, and good compatibility with functional groups. Moreover, it also enables late-stage silylation of some pharmaceuticals, thus providing an excellent route for obtaining valuable pharmaceutical intermediates.

引用

页码：5322 / 5327

页数：6

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