Iron-catalyzed C-F bond silylation and borylation of fluoroarenes

被引：13
|
作者：
Sun, Minghui [1 ]
Tao, Maoling [2 ]
Zhao, Liang [2 ]
Li, Weipiao [2 ]
Liu, Zhengli [1 ]
He, Chun-Yang [2 ]
Feng, Zhang [1 ,3 ,4 ]
机构：
[1] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China
[2] Zunyi Med Univ, Sch Pharm, Gener Drug Res Ctr Guizhou Prov, Key Lab Biocatalysis & Chiral Drug Synth Guizhou, Zunyi 563003, Guizhou, Peoples R China
[3] North Sichuan Med Coll, Sichuan Key Lab Med Imaging, Nanchong 637000, Sichuan, Peoples R China
[4] North Sichuan Med Coll, Sch Preclin Med, Nanchong 637000, Sichuan, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 19期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
HYDROSILYLATION; ACTIVATION; ALKENE; ALKYL; FUNCTIONALIZATION; POLYFLUOROARENES; GENERATION; COMPLEXES; FLUORINE;
D O I：
10.1039/d1qo00839k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Iron-catalyzed functionalization of inert bonds has scarcely been documented. Herein, we report an iron-catalyzed method for the silylation and borylation of (hetero)aromatic fluorides. This protocol features a wide range of substrates, high efficiency, and good compatibility with functional groups. Moreover, it also enables late-stage silylation of some pharmaceuticals, thus providing an excellent route for obtaining valuable pharmaceutical intermediates.
引用
收藏
页码：5322 / 5327
页数：6
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