Activity of Red Nucleus Neurons in the Cat during Postural Corrections

被引:36
|
作者
Zelenin, Pavel V. [1 ]
Beloozerova, Irina N. [2 ]
Sirota, Mikhail G. [2 ]
Orlovsky, Grigori N. [1 ]
Deliagina, Tatiana G. [1 ]
机构
[1] Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden
[2] Barrow Neurol Inst, Phoenix, AZ 85013 USA
来源
JOURNAL OF NEUROSCIENCE | 2010年 / 30卷 / 43期
基金
美国国家卫生研究院; 瑞典研究理事会;
关键词
RUBROSPINAL TRACT; MOTOR CORTEX; MOTONEURONES; LOCOMOTION; MOVEMENT;
D O I
10.1523/JNEUROSCI.2991-10.2010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The dorsal-side-up body posture in standing quadrupeds is maintained by the postural system, which includes spinal and supraspinal mechanisms driven by somatosensory inputs from the limbs. A number of descending tracts can transmit supraspinal commands for postural corrections. The first aim of this study was to understand whether the rubrospinal tract participates in their transmission. We recorded activity of red nucleus neurons (RNNs) in the cat maintaining balance on the periodically tilting platform. Most neurons were identified as rubrospinal ones. It was found that many RNNs were profoundly modulated by tilts, suggesting that they transmit postural commands. The second aim of this study was to examine the contribution of sensory inputs from individual limbs to posture-related RNN modulation. Each RNN was recorded during standing on all four limbs, as well as when two or three limbs were lifted from the platform and could not signal platform displacements. By comparing RNN responses in different tests, we found that the amplitude and phase of responses in the majority of RNNs were determined primarily by sensory input from the corresponding (fore or hind) contralateral limb, whereas inputs from other limbs made a much smaller contribution to RNN modulation. These findings suggest that the rubrospinal system is primarily involved in the intralimb postural coordination, i.e., in the feedback control of the corresponding limb and, to a lesser extent, in the interlimb coordination. This study provides a new insight into the formation of supraspinal motor commands for postural corrections.
引用
收藏
页码:14533 / 14542
页数:10
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