Evaluation of pharmacologic mechanisms to overcome IgG1 antibody (Ab) resistance via quantitative systems pharmacology (QSP) modeling of antibody-dependent cell mediated cytotoxicity (ADCC).

被引：0
|
作者：
Johnson, Kaitlyn E. [1 ]
Ciocanel, Maria Veronica [2 ]
Aponte, Josua [3 ]
Bajeux, Nicolas [4 ]
Meng, Fanwang [5 ]
Bottino, Dean [6 ]
机构：
[1] Univ Texas Austin, Austin, TX 78712 USA
[2] Duke Univ, Durham, NC USA
[3] Indiana Univ, Bloomington, IN USA
[4] Univ Manitoba, Winnipeg, MB, Canada
[5] McMaster Univ, Hamilton, ON, Canada
[6] Takeda Pharmaceut, Cambridge, MA USA
来源：
CANCER RESEARCH | 2021年 / 81卷 / 13期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
231
引用
收藏
页数：2
相关论文
共 36 条
  • [31] IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-HLA Antibody (Ab), Resulting in Inhibition of Anti-HLA Ab-Mediated NK Cell Activation and Ab-Dependent Cell-Mediated Cytotoxicity (ADCC) in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts)
    Ge, S.
    Chu, M.
    Choi, J.
    Louie, S.
    Kang, A.
    Vo, A.
    Peng, A.
    Jordan, S.
    Toyoda, M.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2017, 17 : 533 - 533
  • [32] Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1highCD11b+cells elimination in hepatocellular carcinoma
    Jizhou Tan
    Ting Liu
    Wenzhe Fan
    Jialiang Wei
    Bowen Zhu
    Yafang Liu
    Lingwei Liu
    Xiaokai Zhang
    Songling Chen
    Haibiao Lin
    Yuanqing Zhang
    Jiaping Li
    Acta Pharmaceutica Sinica B, 2023, (02) : 632 - 647
  • [33] Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell- mediated cytotoxicity mediating PD-L1highCD11bD cells elimination in hepatocellular carcinoma
    Tan, Jizhou
    Liu, Ting
    Fan, Wenzhe
    Wei, Jialiang
    Zhu, Bowen
    Liu, Yafang
    Liu, Lingwei
    Zhang, Xiaokai
    Chen, Songling
    Lin, Haibiao
    Zhang, Yuanqing
    Li, Jiaping
    ACTA PHARMACEUTICA SINICA B, 2023, 13 (02) : 632 - 647
  • [34] NK Cell and Ig Interplay in Defense against Herpes Simplex Virus Type 1: Epistatic Interaction of CD16A and IgG1 Allotypes of Variable Affinities Modulates Antibody-Dependent Cellular Cytotoxicity and Susceptibility to Clinical Reactivation
    Moraru, Manuela
    Black, Laurel E.
    Muntasell, Aura
    Portero, Francisca
    Lopez-Botet, Miguel
    Reyburn, Hugh T.
    Pandey, Janardan P.
    Vilches, Carlos
    JOURNAL OF IMMUNOLOGY, 2015, 195 (04): : 1676 - 1684
  • [35] Downregulation of ATP6V1B1 in HER2-overexpressing human breast cancer cell line leads resistance against trastuzumab-mediated antibody-dependent cellular cytotoxicity
    Nishie, Mariko
    Suzuki, Eiji
    Kawaguchi, Kosuke
    Sakamoto, Keiko
    Fukushima, Yuji
    Hattori, Masakazu
    Sugie, Tomoharu
    Toi, Masakazu
    CANCER RESEARCH, 2015, 75
  • [36] High serum miR-19a levels correlated with favorable prognosis in patients with metastatic HER2+breast cancer and might result from effective antibody-dependent cell-mediated cytotoxicity (ADCC) induced by trastuzumab and Th1-mediated antitumor immune response
    Anfossi, S.
    Huo, L.
    Woodward, W. A.
    Ueno, N. T.
    Valero, V.
    Calin, G. A.
    Reuben, J. M.
    CANCER RESEARCH, 2016, 76
1234