Recent Trends in Cyclic Peptides as Therapeutic Agents and Biochemical Tools

被引：67

作者：

Choi, Joon-Seok ^{[1
]}

Joo, Sang Hoon ^{[1
]}

机构：

[1] Daegu Catholic Univ, Coll Pharm, Gyongsan 38430, South Korea

来源：

BIOMOLECULES & THERAPEUTICS | 2020年 / 28卷 / 01期

关键词：

Cyclic peptides; Stapled peptides; Drug lead; Bicyclic peptide; RECEPTOR ANTAGONIST; IN-VITRO; PHAGE SELECTION; DRUG DISCOVERY; INHIBITORS; PROTEIN; IDENTIFICATION; ANGIOGENESIS; DESIGN; MOTIF;

D O I：

10.4062/biomolther.2019.082

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Notable progress has been made in the therapeutic and research applications of cyclic peptides since our previous review. New drugs based on cyclic peptides are entering the market, such as plecanatide, a cyclic peptide approved by the United States Food and Drug Administration in 2017 for the treatment of chronic idiopathic constipation. In this review, we discuss recent developments in stapled peptides, prepared with the use of chemical linkers, and bicyclic/tricyclic peptides with more than two rings. These have widespread applications for clinical and research purposes: imaging, diagnostics, improvement of oral absorption, enzyme inhibition, development of receptor agonist/antagonist, and the modulation of protein-protein interaction or protein-RNA interaction. Many cyclic peptides are expected to emerge as therapeutics and biochemical tools.

引用

页码：18 / 24

页数：7

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