Paternal vs. Maternal Factors in Childhood Atopic Dermatitis

被引：10

作者：

Vaughn, Alexandra R. ^{[1
,2
]}

Sivamani, Raja K. ^{[2
]}

Lio, Peter A. ^{[3
]}

Shi, Vivian Y. ^{[4
]}

机构：

[1] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA

[2] Univ Calif Davis, Dept Dermatol, Davis, CA 95616 USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Dermatol & Pediat, Chicago, IL 60611 USA

[4] Univ Arizona, Dept Med, Dermatol Div, Tucson, AZ 85724 USA

来源：

DERMATITIS | 2017年 / 28卷 / 04期

关键词：

IGE LEVELS; SUSCEPTIBILITY LOCI; HYGIENE HYPOTHESIS; ALLERGIC DISEASES; BETA-SUBUNIT; ECZEMA; ASSOCIATION; RISK; CHILDREN; PREGNANCY;

D O I：

10.1097/DER.0000000000000305

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Atopic dermatitis (AD) is a common inflammatory skin disease that chronically affects children and adults worldwide. Environmental exposures, heritable factors, immune dysregulation, and skin barrier malfunction all contribute to the multifactorial nature of AD. It is known that maternal and paternal influences are important predictors for the risk of AD in offspring. This review examines and compares the evidence and mechanisms behind specific maternal and paternal factors that may contribute to the pathogenesis of AD.

引用

页码：241 / 245

页数：5

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