Tofacitinib as an Adjunct Immunomodulator for Treatment of a Patient with Severe COVID-19: A Case Report

被引：1

作者：

Shrestha, Gentle Sunder ^{[1
]}

Bista, Bidesh ^{[2
]}

Dhungana, Ashesh ^{[3
]}

Poudel, Nimesh ^{[4
]}

Bhattarai, Shraddha ^{[5
]}

Shrestha, Manjit ^{[5
]}

Bhandari, Sandip ^{[6
]}

Vaidya, Binit ^{[7
]}

机构：

[1] Tribhuvan Univ Teaching Hosp, Dept Anaesthesiol, Kathmandu, Nepal

[2] Civi & Serv Hosp Nepal, Kathmandu, Nepal

[3] Natl Acad Med Sci, Bir Hosp, Dept Internal Med, Kathmandu, Nepal

[4] Kathmandu Med Coll & Teaching Hosp, Kathmandu, Nepal

[5] Alka Hosp Pvt Ltd, Lalitpur, Nepal

[6] Shahid Gangalal Natl Heart Ctr, Kathmandu, Nepal

[7] Natl Ctr Rheumat Dis, Kathmandu, Nepal

来源：

JOURNAL OF NEPAL MEDICAL ASSOCIATION | 2021年 / 59卷 / 238期

关键词：

COVID-19; dexamethasone; immunomodulation;

D O I：

10.31729/jnma.6680

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Severe coronavirus disease 2019 can be associated with progressive respiratory failure. In addition to respiratory support and other supportive care, use of corticosteroids has shown to improve outcome. Despite the use of steroids, a significant proportion of patients progressively worsen. Adjunct immunomodulators have been studied in addition to steroids in these patients. Here we present a successful use of tofacitinib, a Janus Kinase inhibitor, in conjunction with dexamethasone for a patient with rapid worsening of respiratory status and with high level of serum inflammatory biomarkers.

引用

页码：593 / 596

页数：4

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