Rapidly progressing bilateral cataracts in a patient with beta thalassemia and pellagra

被引：8

作者：

Athanasiadis, Ioannis

Konstantinidis, Aristeidis

Kyprianou, Ioannis

Robinson, Rosemary

Moschou, Vaia

Kouzi-Koliakos, Kokkona

机构：

[1] Coventry & Warwickshire Univ Hosp NHS Trust, Dept Ophthalmol, Walsgrave Hosp, Coventry, W Midlands, England

[2] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Thessaloniki, Greece

来源：

JOURNAL OF CATARACT AND REFRACTIVE SURGERY | 2007年 / 33卷 / 09期

关键词：

D O I：

10.1016/j.jcrs.2007.05.011

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Soon after the diagnosis of pellagra in a 20-year-old patient with beta thalassemia, bilateral intumescent cataracts rapidly developed. We believe the patient's crystalline lenses were at an increased oxidative state due to iron overload from the thalassemia. Depletion of the lens epithelial cells of an important antioxidative agent (glutathione) as a result of niacin (vitamin B3) deficiency due to pellagra reduced the antioxidative capacity of the lenses. The oxidative damage led to rapid development of cataracts.

引用

页码：1659 / 1661

页数：3

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