Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

被引：23
作者：
Lien, Kuang-Hsu [1 ,2 ]
Yang, Chao-Hui [3 ,4 ]
机构：
[1] Chang Gung Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Chang Gung Mem Hosp,Linkou Branch, Taoyuan 33302, Taiwan
[2] Chang Gung Univ, Coll Med, Grad Inst Clin Med Sci, Taoyuan 33302, Taiwan
[3] Kaohsiung Chang Gung Mem Hosp, Dept Otolaryngol Head & Neck Surg, Kaohsiung 83301, Taiwan
[4] Chang Gung Univ, Coll Med, Kaohsiung 83301, Taiwan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 15期
关键词：
acquired sensorineural hearing loss; noise trauma; ototoxicity; presbycusis; estrogen; cochlea; sexual dimorphism; ESTROGEN-RECEPTOR-ALPHA; PRODUCT OTOACOUSTIC EMISSIONS; GENDER-DIFFERENCES; AUDITORY FUNCTION; OLDER-ADULTS; SUPEROXIDE-DISMUTASE; OVARIECTOMIZED RATS; DEMENTIA PREVENTION; NORD-TRONDELAG; DRUG-DELIVERY;
D O I：
10.3390/ijms22158111
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The triad of noise-generated, drug-induced, and age-related hearing loss is the major cause of acquired sensorineural hearing loss (ASNHL) in modern society. Although these three forms of hearing loss display similar underlying mechanisms, detailed studies have revealed the presence of sex differences in the auditory system both in human and animal models of ASNHL. However, the sexual dimorphism of hearing varies among noise-induced hearing loss (NIHL), ototoxicity, and age-related hearing loss (ARHL). Importantly, estrogen may play an essential role in modulating the pathophysiological mechanisms in the cochlea and several reports have shown that the effects of hormone replacement therapy on hearing loss are complex. This review will summarize the clinical features of sex differences in ASNHL, compare the animal investigations of cochlear sexual dimorphism in response to the three insults, and address how estrogen affects the auditory organ at molecular levels.
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页数：16
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