Identification of antibiotics using small molecule variable ligand display on gold nanoparticles

被引：26

作者：

Bresee, Jamee ^{[2
]}

Maier, Keith E. ^{[2
]}

Melander, Christian ^{[1
]}

Feldheim, Daniel L. ^{[2
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

[2] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 40期

关键词：

RECEPTORS; COMPLEXES;

D O I：

10.1039/c0cc02663h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we describe the use of simple 1-pot thiol exchange reactions to generate a library of mixed ligand-coated gold nanoparticles that was screened for antibiotic activity. A library of 120 nanoparticle conjugates was assembled and antibiotic activity toward E. coli was determined and found to depend upon the combination of thiols assembled onto the nanoparticles. The most active conjugate displayed 99.9% growth inhibition at 0.5 mu M.

引用

页码：7516 / 7518

页数：3

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