Synthesis of immunoregulatory Helicobacter pylori lipopolysaccharide partial structures

被引：26

作者：

Fujimoto, Yukari

Iwata, Masato

Imakita, Noriko

Shimoyama, Atsushi

Suda, Yasuo

Kusumoto, Shoichi

Fukase, Koichi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Sci, Dept Chem, Toyonaka, Osaka 5600043, Japan

[2] Kagoshima Univ, Grad Sch Sci & Engn, Dept Nanostruct & Adv Mat, Kagoshima 890, Japan

[3] Suntory Inst Bioorgan Res, Shimamoto, Osaka 6188503, Japan

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 37期

基金：

日本学术振兴会;

关键词：

LIPID-A; BIOLOGICAL-ACTIVITIES; DIVERGENT SYNTHESIS; ACTIVATION; ANALOGS; LPS; EXPRESSION; TLR4; ACID;

D O I：

10.1016/j.tetlet.2007.07.036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of immunoregulatory glycoconjugates, namely the active entity of lipopolysaccharide (LPS) from Helicobacter pylori was achieved. The results of biological activities of the LPS partial structures provide the structural basis for the immunobiological activity, especially for the immune inhibitory activity of H. pylori LPS. (C) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：6577 / 6581

页数：5

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