The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease

被引：60

作者：

Brinkworth, Jessica F. ^{[1
,2
]}

Barreiro, Luis B. ^{[1
,2
]}

机构：

[1] St Justine Hosp Res Ctr, Montreal, PQ H3T 1C5, Canada

[2] Univ Montreal, Fac Med, Dept Pediat, Montreal, PQ H3T 1J4, Canada

来源：

CURRENT OPINION IN IMMUNOLOGY | 2014年 / 31卷

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; AVIUM SUBSPECIES PARATUBERCULOSIS; TRANSCRIPTION FACTOR ETS-1; SHP2 TYROSINE PHOSPHATASE; RECENT POSITIVE SELECTION; ACYL-COA SYNTHETASE; CROHNS-DISEASE; BOWEL-DISEASE; IRON-DEFICIENCY; CELIAC-DISEASE;

D O I：

10.1016/j.coi.2014.09.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic inflammatory and autoimmune diseases have been the focus of many genome-wide association studies (GWAS) because they represent a significant cause of illness and morbidity, and many are heritable. Almost a decade of GWAS studies suggests that the pathological inflammation associated with these diseases is controlled by a limited number of networked immune system genes. Chronic inflammatory and autoimmune diseases are enigmatic from an evolutionary perspective because they exert a negative affect on reproductive fitness. The persistence of these conditions may be partially explained by the important roles the implicated immune genes play in pathogen defense and other functions thought to be under strong natural selection in humans. The evolutionary reasons for chronic inflammatory and autoimmune disease persistence and uneven distribution across populations are the focus of this review.

引用

页码：66 / 78

页数：13

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