Immunomodulatory Treatments in Epilepsy

被引：27

作者：

Melvin, Joseph J. ^{[1
]}

Hardison, H. Huntley ^{[1
]}

机构：

[1] Drexel Univ, St Christophers Hosp Children, Neurol Sect, Dept Pediat,Coll Med, Philadelphia, PA 19104 USA

来源：

SEMINARS IN PEDIATRIC NEUROLOGY | 2014年 / 21卷 / 03期

关键词：

INTRAVENOUS IMMUNOGLOBULINS; THERAPY; INFECTION; SEIZURES; METHYLPREDNISOLONE; ENCEPHALITIS; MINOCYCLINE; GUIDELINES; RITUXIMAB; CHILDREN;

D O I：

10.1016/j.spen.2014.08.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The role of immunity and inflammation appears to be an integral part of the pathogenic processes associated with some seizures, particularly with refractory epilepsy. Prompt treatment with immunotherapy may lead to better outcomes. Immune treatment options for treatment of epilepsy include therapies such as corticosteroids, immunoglobulins, plasmapheresis, or steroid-sparing drugs such as azathioprine. Recent alternatives have included even more aggressive treatment with cyclophosphamide, anti-pre-B-lymphocyte monoclonal antibody rituximab, and monoclonal antibodies such as efalizumab or natalizumab, which are presently used for other inflammatory disorders. Randomized controlled trials of immunotherapy in presumed autoimmune epilepsy are needed to provide further support for the rapid use of immunotherapy in patients with immune mediated epilepsy. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：232 / 237

页数：6

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