Development, History, and Future of Automated Cell Counters

被引:59
作者
Green, Ralph [1 ]
Wachsmann-Hogiu, Sebastian [2 ]
机构
[1] Univ Calif Davis, UC Davis Med Diagnost, Dept Pathol & Lab Med, Davis Hlth Syst, Sacramento, CA 95817 USA
[2] Univ Calif Davis, Ctr Biophoton, Dept Pathol & Lab Med, Sacramento, CA 95817 USA
关键词
Automated cell counter; Hematology; Blood; Hemoglobin; Electrical impedance counting; Flow cytometry; Point of Care; Light scattering; FLOW-CYTOMETRY; IN-VIVO; BLOOD; VOLUME; CLASSIFICATION;
D O I
10.1016/j.cll.2014.11.003
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Modern automated hematology instruments use either optical methods (light scatter), impedance-based methods based on the Coulter principle (changes in electrical current induced by blood cells flowing through an electrically charged opening), or a combination of both optical and impedance-based methods. Progressive improvement in these instruments has allowed the enumeration and evaluation of blood cells with great accuracy, precision, and speed at very low cost. Future directions of hematology instrumentation include the addition of new parameters and the development of point-of-care instrumentation. In the future, in-vivo analysis of blood cells may allow noninvasive and near-continuous measurements.
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页码:1 / +
页数:11
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