Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

被引：174
|
作者：
Dalrymple, Annette
Wild, Edward J.
Joubert, Richard
Sathasivam, Kirupa
Bjorkqvist, Maria
Petersen, Asa
Jackson, Graham S.
Isaacs, Jeremy D.
Kristiansen, Mark
Bates, Gillian P.
Leavitt, Blair R.
Keir, Geoff
Ward, Malcolm
Tabrizi, Sarah J.
机构：
[1] Natl Hosp Neurol & Neurosurg, Inst Neurol, MRC, Prion Unit, London WC1N 3BG, England
[2] Proteome Sci PLC, Surrey, England
[3] Inst Neurol, Dept Neurodegenerat, London WC1N 3BG, England
[4] Kings Coll London, Guys Hosp, Sch Med, London WC2R 2LS, England
[5] Wallenberg Neurosci Ctr, Dept Expt Med Sci, Neuronal Survival Unit, Lund, Sweden
[6] Univ British Columbia, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 1M9, Canada
[7] Natl Hosp Neurol & Neurosurg, Neuroimmunol Lab, London WC1N 3BG, England
来源：
JOURNAL OF PROTEOME RESEARCH | 2007年 / 6卷 / 07期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
Huntington's disease; plasma; neuroinflammation; proteomics; 2D electrophoresis; LC/MS/MS; MALDI-TOF; ELISA; biomarkers;
D O I：
10.1021/pr0700753
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.
引用
收藏
页码：2833 / 2840
页数：8
相关论文
共 50 条
  • [1] Blood and plasma-based proteomic biomarker research in Alzheimer's disease
    Lista, Simone
    Faltraco, Frank
    Prvulovic, David
    Hampel, Harald
    PROGRESS IN NEUROBIOLOGY, 2013, 101 : 1 - 17
  • [2] Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer’s disease
    Huimin Cai
    Yana Pang
    Qi Wang
    Wei Qin
    Cuibai Wei
    Ying Li
    Tingting Li
    Fangyu Li
    Qigeng Wang
    Yan Li
    Yiping Wei
    Longfei Jia
    Alzheimer's Research & Therapy, 14
  • [3] Proteomic profiling of human plasma for cancer biomarker discovery
    Huang, Zhao
    Ma, Linguang
    Huang, Canhua
    Li, Qifu
    Nice, Edouard C.
    PROTEOMICS, 2017, 17 (06)
  • [4] Proteomic Analysis of Huntington's Disease
    Kumar, Shobhit
    Singh, Priyanka
    Sharma, Shrestha
    Ali, Javed
    Baboota, Sanjula
    Pottoo, Faheem Hyder
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2020, 21 (12) : 1218 - 1222
  • [5] Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer's disease
    Cai, Huimin
    Pang, Yana
    Wang, Qi
    Qin, Wei
    Wei, Cuibai
    Li, Ying
    Li, Tingting
    Li, Fangyu
    Wang, Qigeng
    Li, Yan
    Wei, Yiping
    Jia, Longfei
    ALZHEIMERS RESEARCH & THERAPY, 2022, 14 (01)
  • [6] Lipidomic Profiling of Plasma and Erythrocytes From Septic Patients Reveals Potential Biomarker Candidates
    Mecatti, Giovana Colozza
    Fernandes Messias, Marcia Cristina
    Sant'Anna Paiola, Rafaela Maria
    Figueiredo Angolini, Celio Fernando
    da Silva Cunha, Ildenize Barbosa
    Eberlin, Marcos Nogueira
    Carvalho, Patricia de Oliveira
    BIOMARKER INSIGHTS, 2018, 13
  • [7] Proteomic Profiling of Plasma and Brain Tissue from Alzheimer's Disease Patients Reveals Candidate Network of Plasma Biomarkers
    Chen, Mei
    Xia, Weiming
    JOURNAL OF ALZHEIMERS DISEASE, 2020, 76 (01) : 349 - 368
  • [8] Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration
    Dube, Christabel Thembela
    Gilbert, Hamish T. J.
    Rabbitte, Niamh
    Baird, Pauline
    Patel, Sonal
    Herrera, Jeremy A.
    Baricevic-Jones, Ivona
    Unwin, Richard D.
    Chan, Danny
    Gnanalingham, Kanna
    Hoyland, Judith A.
    Richardson, Stephen M.
    ARTHRITIS RESEARCH & THERAPY, 2025, 27 (01) : 28
  • [9] Proteome Profiling of Serum Reveals Pathological Mechanisms and Biomarker Candidates for Cerebral Small Vessel Disease
    Wang, Yun-chao
    Zhu, Hang-hang
    He, Liu-Chang
    Yao, Ya-ting
    Zhang, Lei
    Xue, Xin-li
    Li, Jing-yi
    Zhang, Li
    Song, Bo
    Shi, Chang-he
    Li, Yu-sheng
    Gao, Yuan
    Yang, Jing-hua
    Xu, Yu-ming
    TRANSLATIONAL STROKE RESEARCH, 2025,
  • [10] Proteomic and metabolomic profiling reveals time-dependent changes in hippocampal metabolism upon paroxetine treatment and biomarker candidates
    Webhofer, Christian
    Gormanns, Philipp
    Reckow, Stefan
    Lebar, Maria
    Maccarrone, Giuseppina
    Ludwig, Tonia
    Puetz, Benno
    Asara, John M.
    Holsboer, Florian
    Sillaber, Inge
    Zieglgaensberger, Walter
    Turck, Christoph W.
    JOURNAL OF PSYCHIATRIC RESEARCH, 2013, 47 (03) : 289 - 298
12345