The Metabolic Landscape of Lung Cancer: New Insights in a Disturbed Glucose Metabolism

被引：101

作者：

Vanhove, Karolien ^{[1
,2
]}

Graulus, Geert-Jan ^{[3
]}

Mesotten, Liesbet ^{[1
,4
]}

Thomeer, Michiel ^{[1
,5
]}

Derveaux, Elien ^{[1
]}

Noben, Jean-Paul ^{[6
]}

Guedens, Wanda ^{[3
]}

Adriaensens, Peter ^{[3
,7
]}

机构：

[1] UHasselt, LCRC, Fac Med & Life Sci, Diepenbeek, Belgium

[2] Algemeen Ziekenhuis Vesalius, Dept Resp Med, Tongeren, Belgium

[3] Hasselt Univ, Inst Mat Res, Biomol Design Grp, Diepenbeek, Belgium

[4] Ziekenhuis Oost Limburg, Dept Nucl Med, Genk, Belgium

[5] Ziekenhuis Oost Limburg, Dept Resp Med, Genk, Belgium

[6] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium

[7] Hasselt Univ, Inst Mat Res, Appl & Analyt Chem, Diepenbeek, Belgium

来源：

FRONTIERS IN ONCOLOGY | 2019年 / 9卷

关键词：

lung cancer; glucose; metabolism; genetic alterations; targeting metabolism; ONE-CARBON METABOLISM; CELL-CYCLE ARREST; PYRUVATE-DEHYDROGENASE; TUMOR-CELLS; SERINE HYDROXYMETHYLTRANSFERASE; TRANSCRIPTIONAL REGULATION; AEROBIC GLYCOLYSIS; ENERGY-METABOLISM; FDG UPTAKE; PHASE-III;

D O I：

10.3389/fonc.2019.01215

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metabolism encompasses the biochemical processes that allow healthy cells to keep energy, redox balance and building blocks required for cell development, survival, and proliferation steady. Malignant cells are well-documented to reprogram their metabolism and energy production networks to support rapid proliferation and survival in harsh conditions via mutations in oncogenes and inactivation of tumor suppressor genes. Despite the histologic and genetic heterogeneity of tumors, a common set of metabolic pathways sustain the high proliferation rates observed in cancer cells. This review with a focus on lung cancer covers several fundamental principles of the disturbed glucose metabolism, such as the "Warburg" effect, the importance of the glycolysis and its branching pathways, the unanticipated gluconeogenesis and mitochondrial metabolism. Furthermore, we highlight our current understanding of the disturbed glucose metabolism and how this might result in the development of new treatments.

引用

页数：19

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