Soluble fractalkine in the plasma of fibromyalgia patients

被引：3

作者：

Garcia, Juan J. ^{[1
]}

Ortega, Eduardo ^{[1
]}

机构：

[1] Univ Extremadura, Fac Sci, Dept Physiol, Immunophysiol Res Grp, E-06071 Badajoz, Spain

来源：

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2014年 / 86卷 / 04期

关键词：

fractalkine; fibromyalgia; biomarker; chemokine; monocyte; CLEAVAGE;

D O I：

10.1590/0001-3765201420130081

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fibromyalgia is a form of non-articular rheumatism in which inflammatory cytokines seem to be involved. However, there is still no analytical specific diagnostic criterion for this disease. The aim was to examine a possible role of fractalkine as a biomarker in fibromyalgia. Plasma levels of soluble fractalkine were compared between women diagnosed with fibromyalgia (n=17) and healthy women (n=10) as controls. Fractalkine released by monocytes was also evaluated. Fibromyalgia patients showed lower plasma fractalkine than healthy women. Since most inflammatory pathologies show elevated plasma levels of soluble fractalkine, the results may contribute towards a differential diagnosis for fibromyalgia.

引用

页码：1915 / 1917

页数：3

共 9 条

[1] Inflammatory/Stress Feedback Dysregulation in Women with Fibromyalgia [J].

Bote, Maria E. ;

Garcia, Juan J. ;

Hinchado, Maria D. ;

Ortega, Eduardo .

NEUROIMMUNOMODULATION, 2012, 19 (06) :343-351

[2]

Garton KJ, 2001, J BIOL CHEM, V276, P37993

[3] The disintegrin-like metalloproteinase ADAM 10 is involved in coinstitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion [J].

Hundhausen, C ;

Misztela, D ;

Berkhout, TA ;

Broadway, N ;

Saftig, P ;

Reiss, K ;

Hartmann, D ;

Fahrenholz, F ;

Postina, R ;

Matthews, V ;

Kallen, KJ ;

Rose-John, S ;

Ludwig, A .

BLOOD, 2003, 102 (04) :1186-1195

[4] Pathological Role of Fractalkine/CX3CL1 in Rheumatic Diseases: A Unique Chemokine with Multiple Functions [J].

Jones, Brian ;

Koch, Alisa E. ;

Ahmed, Salahuddin .

FRONTIERS IN IMMUNOLOGY, 2012, 2

[5] Glia in pathological pain: A role for fractalkine [J].

Milligan, E. D. ;

Sloane, E. M. ;

Watkins, L. R. .

JOURNAL OF NEUROIMMUNOLOGY, 2008, 198 (1-2) :113-120

[6] The classification of fibromyalgia syndrome [J].

Mueller, W. ;

Schneider, E. M. ;

Stratz, T. .

RHEUMATOLOGY INTERNATIONAL, 2007, 27 (11) :1005-1010

[7]

Ortega E, 2009, EXERC IMMUNOL REV, V15, P42

[8] Neuroendocrine and immune aspects of fibromyalgia [J].

van West, D ;

Maes, M .

BIODRUGS, 2001, 15 (08) :521-531

[9] The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity [J].

Wolfe, Frederick ;

Clauw, Daniel J. ;

Fitzcharles, Mary-Ann ;

Goldenberg, Don L. ;

Katz, Robert S. ;

Mease, Philip ;

Russell, Anthony S. ;

Russell, I. Jon ;

Winfield, John B. ;

Yunus, Muhammad B. .

ARTHRITIS CARE & RESEARCH, 2010, 62 (05) :600-610

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