Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs

被引:5
作者
Hadizadeh, Dariusch Reza [1 ]
Keil, Vera Catharina [1 ]
Jost, Gregor [2 ]
Pietsch, Hubertus [2 ]
Weibrecht, Martin [3 ]
Marx, Christian [1 ]
Willinek, Winfried [4 ]
机构
[1] Univ Bonn, Dept Radiol, Sigmund Freud Str 25, D-53113 Bonn, Germany
[2] Bayer AG, MR & CT Contrast Media Res, Berlin, Germany
[3] Philips Technol GmbH Innovat Technol, Res Labs, Aachen, Germany
[4] Krankenhaus Barmherzigen Brueder, Ctr Radiol Neuroradiol Sonog & Nucl Med, Trier, Germany
来源
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN | 2018年 / 190卷 / 08期
关键词
contrast agents; gadobutrol; experimental animal model; magnetic resonance angiography; gadopentetate dimeglumine;
D O I
10.1055/a-0631-4707
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose Quantitative and qualitative analysis of gadopentetate dimeglumine (GD) versus standard-dose (sGb) and halfdose (hGb) gadobutrol in thoracoabdominal time-resolved contrast-enhanced magnetic resonance angiography (4D-MRA) with dynamic computed tomography (dCT) as the quantitative reference in minipigs. Materials and Methods 7 anesthetized Goettingen minipigs received thoracoabdominal dCT (0.37 s rotation time) and transverse 4D-MRA (0.3 s/dynamic frame;) using sGb and hGb. 8 other minipigs received coronal 4D-MRA (1.3 s/dynamic frame; sGb, hGb, SGD). dCT attenuation levels were converted into absolute gadolinium concentrations and compared to 4D-MRA peak signal intensities (SI). Bolus lengths were quantified by full width at half maximum (FWHM) measurements. After this comparison of dose effects on SI in transverse 4D-MRA, coronal 4D-MRAs were analyzed regarding both quantitative and qualitative parameters. Results In dCT (transverse 4D-MRA) hGb showed 39.0 % (14.5 %) lower arterial peak gadolinium concentrations (peak SIs) and 20.6 % (33.8 %) shorter FWHM compared to sGb. The difference was due to peak plateaus or reversals in 4D-MRA in 5/7 animals. While sGb led to the highest peak SIs, image quality ratings of arteries were rated similarly high with all contrast agent protocols despite a slightly higher SI with sGb. In contrast, venous peak SIs and image quality ratings were significantly higher when using sGb. Conclusion Peak Gd concentrations and 4D-MRA peak SIs are highest with sGB. These differences are most evident in the venous phase leading to superior image quality in multiphase 4D-MRA.
引用
收藏
页码:747 / 757
页数:11
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