Improved Stability and Photodynamic Activity of Water-Soluble 5,15-Diazaporphyrins Incorporated in β-(1,3-1,6)-d-Glucan with On-Off Switch

被引：20

作者：

Hino, Shodai ^{[1
]}

Satake, Shuhei ^{[1
]}

Shinmori, Hideyuki ^{[2
]}

Kawabata, Shigeki ^{[3
]}

Koumoto, Kazuya ^{[4
]}

Suzuki, Toshio ^{[5
]}

Nagasaki, Takeshi ^{[5
]}

Sugikawa, Kouta ^{[1
]}

Kawasaki, Riku ^{[1
]}

Ikeda, Atsushi ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Engn, Dept Appl Chem, 1-4-1 Kagamiyama, Higashihiroshima, Hiroshima 7398527, Japan

[2] Univ Yamanashi, Grad Fac Interdisciplinary Res, Fac Life & Environm Sci, Dept Biotechnol, 4-4-37 Takeda, Kofu, Yamanashi 4008510, Japan

[3] Toyama Prefectural Univ, Fac Engn, Dept Liberal Arts & Sci, 5180 Kurokawa, Imizu, Toyama 9390398, Japan

[4] Konan Univ, FIRST, Dept Nanobiochem, 7-1-20 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan

[5] Osaka City Univ, Grad Sch Engn, Dept Appl Chem & Bioengn, Sumiyoshi Ku, 3-3-138 Sugimoto, Osaka 5588585, Japan

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2020年 / 15卷 / 03期

关键词：

aggregation; fluorescent probes; host-guest systems; polysaccharide; porphyrinoids; WALLED CARBON NANOTUBES; ONE-DIMENSIONAL HOST; LIPOSOMAL MEMBRANES; GAMMA-CYCLODEXTRIN; SCHIZOPHYLLAN; BETA-1,3-GLUCAN; COMPLEXATION; DERIVATIVES; ACETATE; CURDLAN;

D O I：

10.1002/asia.201901582

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

5,15-Diazaporphyrins, which have a large absorption at wavelengths over 600 nm, were dissolved in water by complex formation with beta-(1,3-1,6)-d-glucans. Aqueous solutions of these complexes were relatively stable compared with their trimethyl-beta-cyclodextrin-complexed analogues. beta-Glucan-complexed diazaporphyrins showed quenched fluorescence and had low singlet-oxygen-generation abilities owing to random self-aggregation. However, external stimuli, such as the presence of liposomes or intracellular uptake, restored the fluorescence and singlet-oxygen-generation abilities of beta-glucan-complexed diazaporphyrins. Consequently, beta-glucan-complexed diazaporphyrins showed very high photodynamic activities toward HeLa cells.

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页码：365 / 370

页数：6

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