Analysis of systemic and local odontogenic infection complications requiring hospital care

被引:77
作者
Seppanen, Lotta [1 ]
Lauhio, Anneli [2 ]
Lindqvist, Christian [3 ,4 ]
Suuronen, Riitta [5 ,6 ]
Rautemaa, Riina [1 ,4 ]
机构
[1] Univ Helsinki, Haartman Inst, Dept Bacteriol & Immunol, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Cent Hosp, Dept Med, Div Infect Dis, FIN-00029 Helsinki, Finland
[3] Univ Helsinki, Inst Dent, FIN-00014 Helsinki, Finland
[4] Univ Helsinki, Cent Hosp, Dept Oral & Maxillofacial Dis, FIN-00029 Helsinki, Finland
[5] Univ Tampere, Regea Inst Regenerat Med, FIN-33520 Tampere, Finland
[6] Tampere Univ Hosp, FIN-33520 Tampere, Finland
关键词
antibiotic prophylaxis; bacteraemia; dental infection; distant site infection; endocarditis; hospital care; metastatic infection; septicaemia; severe odontogenic infection;
D O I
10.1016/j.jinf.2008.06.002
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objective: Analysis of systemic and local odontogenic infection complications requiring hospital care. Methods: All cases of odontogenic infections requiring hospital care, which were adjudicated in the Finnish Patient Insurance Centre during 2000-2003, were analysed. Patient characteristics, and the course and outcome of infection were reviewed. Results: The study material consisted of 35 patient cases; 15 mate, 20 female; mean age 38.4 (16-67)years. The mean length of hospital stay was 14.8 (2-81) days. Nine patients required intensive care for mean 6.2 (2-19) days. Twenty-five (71%) patients developed local infection complications with cellulitis and abscess formation, and 10 (29%) patients a generalised or metastatic infection complication. The length of hospital stay among patients with systemic complications was longer than with local complications, 30.2 (2-81) days vs. 8.0 (2-34) days (p = 0.0144). All patients with local complications survived but three of the 10 patients with systemic complications died. Medically compromised patients with underlying disease developed more often systemic infection complications than previously healthy patients (p = 0.0028). Conclusions: Medically compromised patients appear more susceptible to systemic rather than local infection complications with a need for significantly longer hospital stay and with an increased risk for fatal complications. (c) 2008 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:116 / 122
页数:7
相关论文
共 37 条
[1]   ORAL INFECTIONS AND SEPTICEMIA IN IMMUNOCOMPROMISED PATIENTS WITH HEMATOLOGIC MALIGNANCIES [J].
BERGMANN, OJ .
JOURNAL OF CLINICAL MICROBIOLOGY, 1988, 26 (10) :2105-2109
[2]   Endodontics and infective endocarditis - is antimicrobial chemoprophylaxis required? [J].
Brincat, M. ;
Savarrio, L. ;
Saunders, W. .
INTERNATIONAL ENDODONTIC JOURNAL, 2006, 39 (09) :671-682
[3]   Death from overwhelming odontogenic sepsis: a case report [J].
Carter, L. ;
Lowis, E. .
BRITISH DENTAL JOURNAL, 2007, 203 (05) :241-242
[4]  
CHOW AW, 2005, PRINCIPLES PRACTICE, P787
[5]   Are dental infections a cause of brain abscess? Case report and review of the literature [J].
Corson, MA ;
Postlethwaite, KP ;
Seymour, RA .
ORAL DISEASES, 2001, 7 (01) :61-65
[6]   Bacteremia due to periodontal probing: A clinical and microbiological investigation [J].
Daly, CG ;
Mitchell, DH ;
Highfield, JE ;
Grossberg, DE ;
Stewart, D .
JOURNAL OF PERIODONTOLOGY, 2001, 72 (02) :210-214
[7]   Comparative efficacies of amoxicillin, clindamycin, and moxifloxacin in prevention of bacteremia following dental extractions [J].
Dios, P. Diz ;
Carmona, I. Tomas ;
Posse, J. Limeres ;
Henriquez, J. Medina ;
Feijoo, J. Fernandez ;
Fernandez, M. Alvarez .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (09) :2996-3002
[8]  
Donnelly JP, 2005, PRINCIPLES PRACTICE, P3421
[9]   Estimated risk of endocarditis in adults with predisposing cardiac conditions undergoing dental procedures with or without antibiotic prophylaxis [J].
Duval, Xavier ;
Alla, F. ;
Hoen, B. ;
Danielou, F. ;
Larrieu, S. ;
Delahaye, F. ;
Leport, C. ;
Briancon, S. .
CLINICAL INFECTIOUS DISEASES, 2006, 42 (12) :E102-E107
[10]   Severe odontogenic infections, part 2: Prospective outcomes study [J].
Flynn, Thomas R. ;
Shanti, Rabie M. ;
Hayes, Catherine .
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2006, 64 (07) :1104-1113