Metastable single-chain polymer nanoparticles prepared by dynamic cross-linking with nor-seco-cucurbit[10]uril

被引：64

作者：

Appel, Eric A. ^{[1
]}

del Barrio, Jesus ^{[1
]}

Dyson, Joseph ^{[1
]}

Isaacs, Lyle ^{[2
]}

Scherman, Oren A. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Melville Lab Polymer Synth, Cambridge CB2 1EW, England

[2] Univ Maryland, Dept Chem, College Pk, MD 20742 USA

来源：

CHEMICAL SCIENCE | 2012年 / 3卷 / 07期

基金：

英国工程与自然科学研究理事会; 美国国家科学基金会;

关键词：

WATER;

D O I：

10.1039/c2sc20285a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present the preparation of metastable single-chain polymeric nanoparticles through stimuli-responsive and reversible intramolecular cross-linking of a single polymer chain in water. Functionalisation of poly(N-hydroxyethylacrylamide) polymers with viologen, followed by addition of nor-seco-cucurbit[10]uril allows for facile preparation of nanoparticles through specific and tightly binding 2 : 1 homo-ternary complexes. Particle sizes can be readily tuned through either polymer molecular weight or degree of cross-linking. By virtue of the supramolecular nature of the intramolecular cross-linking in water, the formation of these metastable nanoparticles represents a step towards the development of synthetic polymers with aqueous phase behaviour analogous to the self folding of biomacromolecules.

引用

页码：2278 / 2281

页数：4

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