Metastable single-chain polymer nanoparticles prepared by dynamic cross-linking with nor-seco-cucurbit[10]uril

被引：64

作者：

Appel, Eric A. ^{[1
]}

del Barrio, Jesus ^{[1
]}

Dyson, Joseph ^{[1
]}

Isaacs, Lyle ^{[2
]}

Scherman, Oren A. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Melville Lab Polymer Synth, Cambridge CB2 1EW, England

[2] Univ Maryland, Dept Chem, College Pk, MD 20742 USA

来源：

CHEMICAL SCIENCE | 2012年 / 3卷 / 07期

基金：

美国国家科学基金会; 英国工程与自然科学研究理事会;

关键词：

WATER;

D O I：

10.1039/c2sc20285a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present the preparation of metastable single-chain polymeric nanoparticles through stimuli-responsive and reversible intramolecular cross-linking of a single polymer chain in water. Functionalisation of poly(N-hydroxyethylacrylamide) polymers with viologen, followed by addition of nor-seco-cucurbit[10]uril allows for facile preparation of nanoparticles through specific and tightly binding 2 : 1 homo-ternary complexes. Particle sizes can be readily tuned through either polymer molecular weight or degree of cross-linking. By virtue of the supramolecular nature of the intramolecular cross-linking in water, the formation of these metastable nanoparticles represents a step towards the development of synthetic polymers with aqueous phase behaviour analogous to the self folding of biomacromolecules.

引用

页码：2278 / 2281

页数：4

共 25 条

[1] Formation of Single-Chain Polymer Nanoparticles in Water through Host-Guest Interactions [J].

Appel, Eric A. ;

Dyson, Joseph ;

del Barrio, Jesus ;

Walsh, Zarah ;

Scherman, Oren A. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (17) :4185-4189

[2] High Molecular Weight Polyacrylamides by Atom Transfer Radical Polymerization: Enabling Advancements in Water-Based Applications [J].

Appel, Eric A. ;

del Barrio, Jesus ;

Loh, Xian Jun ;

Dyson, Joseph ;

Scherman, Oren A. .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2012, 50 (01) :181-186

[3] Supramolecular Cross-Linked Networks via Host-Guest Complexation with Cucurbit[8]uril [J].

Appel, Eric A. ;

Biedermann, Frank ;

Rauwald, Urs ;

Jones, Samuel T. ;

Zayed, Jameel M. ;

Scherman, Oren A. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (40) :14251-14260

[4]

Beck B. J., 2003, J AM CHEM SOC, V46, P13922

[5] Facile Preparation of Nanoparticles by Intramolecular Cross-Linking of Isocyanate Functionalized Copolymers [J].

Beck, J. Benjamin ;

Killops, Kato L. ;

Kang, Taegon ;

Sivanandan, Kulandaivelu ;

Bayles, Andrea ;

Mackay, Michael. E. ;

Wooley, Karen L. ;

Hawker, Craig J. .

MACROMOLECULES, 2009, 42 (15) :5629-5635

[6] Postpolymerization Modification of Hydroxyl-Functionalized Polymers with Isocyanates [J].

Biedermann, Frank ;

Appel, Eric A. ;

del Barrio, Jesus ;

Gruendling, Till ;

Barner-Kowollik, Christopher ;

Scherman, Oren A. .

MACROMOLECULES, 2011, 44 (12) :4828-4835

[7] Supramolecular Polymerization [J].

De Greef, Tom F. A. ;

Smulders, Maarten M. J. ;

Wolffs, Martin ;

Schenning, Albert P. H. J. ;

Sijbesma, Rint P. ;

Meijer, E. W. .

CHEMICAL REVIEWS, 2009, 109 (11) :5687-5754

[8] Tuning the Size of Supramolecular Single-Chain Polymer Nanoparticles [J].

Foster, E. Johan ;

Berda, Erik B. ;

Meijer, E. W. .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2011, 49 (01) :118-126

[9] Metastable Supramolecular Polymer Nanoparticles via Intramolecular Collapse of Single Polymer Chains [J].

Foster, E. Johan ;

Berda, Erik B. ;

Meijer, E. W. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (20) :6964-+

[10] Macroscopic self-assembly through molecular recognition [J].

Harada, Akira ;

Kobayashi, Ryosuke ;

Takashima, Yoshinori ;

Hashidzume, Akihito ;

Yamaguchi, Hiroyasu .

NATURE CHEMISTRY, 2011, 3 (01) :34-37

← 1 2 3 →