Effect of macronutrients, age, and obesity on 6- and 24-h postprandial glucose metabolism in cats

被引:28
作者
Hoenig, Margarethe [1 ,2 ]
Jordan, Erin T. [2 ]
Glushka, John [3 ]
Kley, Saskia [2 ]
Patil, Avinash [4 ]
Waldron, Mark [4 ,5 ]
Prestegard, James H. [3 ]
Ferguson, Duncan C. [6 ]
Wu, Shaoxiong [7 ]
Olson, Darin E. [8 ,9 ]
机构
[1] Univ Illinois, Coll Vet Med, Dept Vet Clin Med, Urbana, IL 61802 USA
[2] Univ Georgia, Coll Vet Med, Dept Physiol & Pharmacol, Athens, GA 30602 USA
[3] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA
[4] Nestle Purina Petcare, St Louis, MO USA
[5] Nestle Res Ctr, CH-1000 Lausanne, Switzerland
[6] Univ Illinois, Coll Vet Med, Dept Vet Biosci, Urbana, IL 61802 USA
[7] Emory Univ, Emory NMR Res Ctr, Atlanta, GA 30322 USA
[8] Emory Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipids, Atlanta, GA USA
[9] Atlanta Vet Affairs Med Ctr, Atlanta, GA USA
关键词
nuclear magnetic resonance spectroscopy; adipocytokines; indirect calorimetry; glycogenolysis; insulin resistance; endogenous glucose production; NUCLEAR-MAGNETIC-RESONANCE; PLASMA LEPTIN CONCENTRATION; FELIS-SILVESTRIS-CATUS; INSULIN-RESISTANCE; LIVER-GLYCOGEN; BODY-FAT; ADIPONECTIN CONCENTRATION; HEPATIC GLYCOGENOLYSIS; POSTABSORPTIVE STATE; DIETARY-PROTEIN;
D O I
10.1152/ajpregu.00342.2011
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Hoenig M, Jordan ET, Glushka J, Kley S, Patil A, Waldron M, Prestegard JH, Ferguson DC, Wu S, Olson DE. Effect of macronutrients, age, and obesity on 6- and 24-h postprandial glucose metabolism in cats. Am J Physiol Regul Integr Comp Physiol 301: R1798-R1807, 2011. First published September 21, 2011; doi:10.1152/ajpregu.00342.2011.-Obesity and age are risk factors for feline diabetes. This study aimed to test the hypothesis that age, long-term obesity, and dietary composition would lead to peripheral and hepatorenal insulin resistance, indicated by higher endogenous glucose production (EGP) in the fasted and postprandial state, higher blood glucose and insulin, and higher leptin, free thyroxine, and lower adiponectin concentrations. Using triple tracer-(H2O)-H-2, [U-C-13(3)] propionate, and [3,4-C-13(2)] glucose infusion, and indirect calorimetry-we investigated carbohydrate and fat metabolic pathways in overnight-fasted neutered cats (13 young lean, 12 old lean, and 12 old obese), each fed three different diets (high protein with and without polyunsaturated fatty acids, and high carbohydrate) in a crossover design. EGP was lowest in fasted and postprandial obese cats despite peripheral insulin resistance, indicated by hyperinsulinemia. Gluconeogenesis was the most important pathway for EGP in all groups, but glycogen contributed significantly. Insulin and leptin concentrations were higher in old than in young lean cats; adiponectin was lowest in obese cats but surprisingly highest in lean old cats. Diet had little effect on metabolic parameters. We conclude that hepatorenal insulin resistance does not develop in the fasted or postprandial state, even in long-term obese cats, allowing the maintenance of euglycemia through lowering EGP. Glycogen plays a major role in EGP, especially in lean fasted cats, and in the postprandial state. Aging may predispose to insulin resistance, which is a risk factor for diabetes in cats. Mechanisms underlying the high adiponectin of healthy old lean cats need to be further explored.
引用
收藏
页码:R1798 / R1807
页数:10
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