ATR: an essential regulator of genome integrity

被引：1372

作者：

Cimprich, Karlene A. ^{[1
]}

Cortez, David ^{[2
]}

机构：

[1] Stanford Univ, Dept Chem & Syst Biol, Clark Ctr, Sch Med, Stanford, CA 94305 USA

[2] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 08期

关键词：

D O I：

10.1038/nrm2450

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genome maintenance is a constant concern for cells, and a coordinated response to DNA damage is required to maintain cellular viability and prevent disease. The ataxia-telangiectasia mutated (ATM) and ATM and RAD3-related (ATR) protein kinases act as master regulators of the DNA-damage response by signalling to control cell-cycle transitions, DNA replication, DNA repair and apoptosis. Recent studies have provided new insights into the mechanisms that control ATR activation, have helped to explain the overlapping but non-redundant activities of ATR and ATM in DNA-damage signalling, and have clarified the crucial functions of ATR in maintaining genome integrity.

引用

页码：616 / 627

页数：12

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