Victims of War: Dehydroepiandrosterone Concentrations in Hair and Their Associations with Trauma Sequelae in Palestinian Adolescents Living in the West Bank

被引:12
作者
Schindler, Lena [1 ]
Shaheen, Mohammed [2 ]
Saar-Ashkenazy, Rotem [3 ,4 ,5 ]
Odeh, Kifah Bani [2 ]
Sass, Sophia-Helen [1 ]
Friedman, Alon [3 ,4 ,6 ]
Kirschbaum, Clemens [1 ]
机构
[1] Tech Univ Dresden, Fac Psychol, D-01069 Dresden, Germany
[2] Al Quds Univ, Fac Publ Hlth, POB 4006, Abu Dees 90612, West Bank, Palestine
[3] Ben Gurion Univ Negev, Dept Cognit Neurosci, POB 653, IL-8410501 Beer Sheva, Israel
[4] Ben Gurion Univ Negev, Zlotowski Ctr Neurosci, POB 653, IL-8410501 Beer Sheva, Israel
[5] Ashkelon Acad Coll, Fac Social Work, IL-7821100 Ashqelon, Israel
[6] Dalhousie Univ, Fac Med, Dept Med Neurosci, POB 15000, Halifax, NS B3H 4R2, Canada
关键词
DHEA; cortisol; hair; traumatic stress; posttraumatic stress disorder; violent conflict; coping; POSTTRAUMATIC-STRESS-DISORDER; OF-THE-ART; CORTISOL CONCENTRATIONS; MAJOR DEPRESSION; STEROID-HORMONES; HPA-AXIS; S LEVELS; DHEA-S; COHERENCE; WOMEN;
D O I
10.3390/brainsci9020020
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Due to its anti-glucocorticoid properties, the steroid hormone dehydroepiandrosterone (DHEA) might play a role for coping with traumatic stress and posttraumatic stress disorder (PTSD). The majority of studies report elevated DHEA secretion and decreased cortisol/DHEA ratio associated with traumatic stress, however, contrasting results have also been published. One reason for this heterogeneity might be that in past studies, DHEA has been measured in plasma or saliva samples reflecting acute hormone levels. In comparison, the current study assessed the hair levels of DHEA and cortisol as long-term markers along with self-reported data on psychopathology and coping in 92 female adolescents aged 11-16 from the West Bank affected by the Israeli-Palestinian conflict. Results showed that trauma-exposed individuals had significantly higher DHEA levels (p = 0.013) and lower cortisol/DHEA ratios (p = 0.036) than participants from the non-trauma group. Furthermore, DHEA and cortisol/DHEA ratio emerged as associated with trauma load and timing, but not with coping. By applying the novel method of DHEA analysis from hair samples, this study adds to the growing literature on the interplay of DHEA, cortisol, traumatic stress and coping, and provides valuable starting points for further research.
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页数:13
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