Interleukin-6 in oral diseases: a review

被引：122
|
作者：
Nibali, L. [1 ,2 ]
Fedele, S. [2 ,3 ]
D'Aiuto, F. [1 ,2 ]
Donos, N. [1 ,2 ]
机构：
[1] UCL, Periodontol Unit, UCL Eastman Dent Inst, London WC1X 8LD, England
[2] UCL, Dept Clin Res, UCL Eastman Dent Inst, London WC1X 8LD, England
[3] UCL, Oral Med Unit, UCL Eastman Dent Inst, London WC1X 8LD, England
来源：
ORAL DISEASES | 2012年 / 18卷 / 03期
关键词：
interleukin-6; oral diseases; periodontitis; lichen planus; oral cancer; Sjogren's syndrome; TUMOR-NECROSIS-FACTOR; FUNCTIONAL GENE POLYMORPHISMS; GINGIVAL CREVICULAR FLUID; B-DEPENDENT CYTOKINES; RECEPTOR IL-6R GENE; HUMAN DENTAL-PULP; LICHEN-PLANUS; FACTOR-ALPHA; PERIODONTAL-DISEASE; TNF-ALPHA;
D O I：
10.1111/j.1601-0825.2011.01867.x
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Interleukin-6 (IL-6) is a pleomorphic cytokine involved in a number of physiologic and pathologic processes including response to trauma and infection and development and progression of inflammation and malignancy. IL-6 is emerging as an important mediator and novel therapeutic target for chronic inflammatory diseases and cancer. The present study reviews the available evidence regarding the association between IL-6 and a range of oral diseases including infections (periodontal disease and endodontic infections), immunologically mediated disorders (oral lichen planus and Sjogren's syndrome) and malignancy (oral cancer and precancer). The role of common genetic variants of IL-6 in determining individual susceptibility to certain oral diseases, as well as novel therapeutic strategies based on IL-6 inhibition are also discussed. Oral Diseases (2012) 18, 236-243
引用
收藏
页码：236 / 243
页数：8
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