Non-synonymous mutations mapped to chromosome X associated with andrological and growth traits in beef cattle

被引：29

作者：

Ferreira de Camargo, Gregorio Miguel ^{[1
,2
,3
]}

Porto-Neto, Laercio R. ^{[2
]}

Kelly, Matthew J. ^{[3
]}

Bunch, Rowan J. ^{[2
]}

McWilliam, Sean M. ^{[2
]}

Tonhati, Humberto ^{[1
]}

Lehnert, Sigrid A. ^{[2
]}

Fortes, Marina R. S. ^{[3
]}

Moore, Stephen S. ^{[4
]}

机构：

[1] Univ Estadual Paulista Unesp, Dept Zootecnia, BR-14884900 Jaboticabal, SP, Brazil

[2] CSIRO, Agr Flagship, St Lucia, Qld 4067, Australia

[3] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia

[4] Univ Queensland, Ctr Anim Sci, Queensland Alliance Agr & Food Innovat, Brisbane, Qld 4067, Australia

来源：

BMC GENOMICS | 2015年 / 16卷

基金：

巴西圣保罗研究基金会;

关键词：

Non-synonymous SNP; X chromosome; Bos taurus indicus; Scrotal circumference; Sperm morphology; REPRODUCTIVE TRAITS; GENETIC-PARAMETERS; MEIOTIC FAILURE; EXPRESSION; STAYABILITY; SELECTION; VARIANTS; PUBERTY; TESTIS;

D O I：

10.1186/s12864-015-1595-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: Previous genome-wide association analyses identified QTL regions in the X chromosome for percentage of normal sperm and scrotal circumference in Brahman and Tropical Composite cattle. These traits are important to be studied because they are indicators of male fertility and are correlated with female sexual precocity and reproductive longevity. The aim was to investigate candidate genes in these regions and to identify putative causative mutations that influence these traits. In addition, we tested the identified mutations for female fertility and growth traits. Results: Using a combination of bioinformatics and molecular assay technology, twelve non-synonymous SNPs in eleven genes were genotyped in a cattle population. Three and nine SNPs explained more than 1% of the additive genetic variance for percentage of normal sperm and scrotal circumference, respectively. The SNPs that had a major influence in percentage of normal sperm were mapped to LOC100138021 and TAF7L genes; and in TEX11 and AR genes for scrotal circumference. One SNP in TEX11 was explained similar to 13% of the additive genetic variance for scrotal circumference at 12 months. The tested SNP were also associated with weight measurements, but not with female fertility traits. Conclusions: The strong association of SNPs located in X chromosome genes with male fertility traits validates the QTL. The implicated genes became good candidates to be used for genetic evaluation, without detrimentally influencing female fertility traits.

引用

页数：10

共 39 条

[1] ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over [J].

Adelman, Carrie A. ;

Petrini, John H. J. .

PLOS GENETICS, 2008, 4 (03)

[2] Epistasis between calpain 1 and its inhibitor calpastatin within breeds of cattle [J].

Barendse, W. ;

Harrison, B. E. ;

Hawken, R. J. ;

Ferguson, D. M. ;

Thompson, J. M. ;

Thomas, M. B. ;

Bunch, R. J. .

GENETICS, 2007, 176 (04) :2601-2610

[3]

Brumatti R.C., 2011, Arch. zootec., V60, P205, DOI 10.4321/s0004-05922011000200005

[4]

Brumatti RC, 2013, LIVEST RES RURAL DEV, V25, P125

[5] Male Reproductive Traits and Their Relationship to Reproductive Traits in Their Female Progeny: A Systematic Review [J].

Burns, B. M. ;

Gazzola, C. ;

Holroyd, R. G. ;

Crisp, J. ;

McGowan, M. R. .

REPRODUCTION IN DOMESTIC ANIMALS, 2011, 46 (03) :534-553

[6] Genetic associations between stayability and reproductive and growth traits in Canchim beef cattle [J].

Buzanskas, M. E. ;

Grossi, D. A. ;

Baldi, F. ;

Barrozo, D. ;

Silva, L. O. C. ;

Torres Junior, R. A. A. ;

Munari, D. P. ;

Alencar, M. M. .

LIVESTOCK SCIENCE, 2010, 132 (1-3) :107-112

[7] Male traits and herd reproductive capability in tropical beef cattle. 2. Genetic parameters of bull traits [J].

Corbet, N. J. ;

Burns, B. M. ;

Johnston, D. J. ;

Wolcott, M. L. ;

Corbet, D. H. ;

Venus, B. K. ;

Li, Y. ;

McGowan, M. R. ;

Holroyd, R. G. .

ANIMAL PRODUCTION SCIENCE, 2013, 53 (02) :101-113

[8] Impacts of Reproductive Technologies on Beef Production in the United States [J].

Dahlen, Carl ;

Larson, Jamie ;

Lamb, G. Cliff .

CURRENT AND FUTURE REPRODUCTIVE TECHNOLOGIES AND WORLD FOOD PRODUCTION, 2014, 752 :97-114

[9] Evidence for pleiotropism and recent selection in the PLAG1 region in Australian Beef cattle [J].

Fortes, M. R. S. ;

Kemper, K. ;

Sasazaki, S. ;

Reverter, A. ;

Pryce, J. E. ;

Barendse, W. ;

Bunch, R. ;

McCulloch, R. ;

Harrison, B. ;

Bolormaa, S. ;

Zhang, Y. D. ;

Hawken, R. J. ;

Goddard, M. E. ;

Lehnert, S. A. .

ANIMAL GENETICS, 2013, 44 (06) :636-647

[10] Genome-wide association study for inhibin, luteinizing hormone, insulin-like growth factor 1, testicular size and semen traits in bovine species [J].

Fortes, M. R. S. ;

Reverter, A. ;

Kelly, M. ;

McCulloch, R. ;

Lehnert, S. A. .

ANDROLOGY, 2013, 1 (04) :644-650

← 1 2 3 4 →