Organoid culture systems to study host-pathogen interactions

被引：130

作者：

Duttal, Devanjali ^{[1
]}

Clevers, Hans ^{[1
,2
]}

机构：

[1] Royal Netherlands Acad Arts & Sci & Univ, Hubrecht Inst, Amsterdam, Netherlands

[2] Utrecht Med Ctr, NL-3584 CT Utrecht, Netherlands

来源：

CURRENT OPINION IN IMMUNOLOGY | 2017年 / 48卷

关键词：

PLURIPOTENT STEM-CELLS; ZIKA VIRUS-INFECTION; CEREBRAL ORGANOIDS; IN-VITRO; INTESTINAL ORGANOIDS; CLOSTRIDIUM-DIFFICILE; NEURAL PROGENITORS; BRAIN ORGANOIDS; HUMAN LIVER; DISEASE;

D O I：

10.1016/j.coi.2017.07.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent advances in host microbe interaction studies in organoid cultures have shown great promise and have laid the foundation for much more refined future studies using these systems. Modeling of Zika virus (ZIKV) infection in cerebral organoids have helped us understand its association with microcephaly. Similarly, the pathogenesis of bacterial (Helicobacter pylori, Clostridium difficile) and viral (Norovirus, Rotaviruses) infections have been precisely dissected in organoid cultures. Additionally, direct associations between microbial colonization of tissues and diseases like cancer have also been deciphered. Here we discuss the most recent and striking studies on host microbe interactions in organoid cultures, highlighting various methods which can be used for developing microbe-organoid co-culture systems.

引用

页码：15 / 22

页数：8

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