Mast cells and dendritic cells form synapses that facilitate antigen transfer for T cell activation

被引:79
作者
Carroll-Portillo, Amanda [1 ]
Cannon, Judy L. [1 ,2 ,3 ]
te Riet, Joost [4 ]
Holmes, Anna [1 ]
Kawakami, Yuko [5 ]
Kawakami, Toshiaki [5 ,6 ]
Cambi, Alessandra [4 ]
Lidke, Diane S. [1 ,3 ]
机构
[1] Univ New Mexico, Sch Med, Dept Pathol, Albuquerque, NM 87131 USA
[2] Univ New Mexico, Sch Med, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA
[3] Univ New Mexico, Canc Res & Treatment Ctr, Albuquerque, NM 87131 USA
[4] Radboud Univ Nijmegen Med Ctr, Radboud Inst Mol Life Sci, Dept Tumor Immunol, NL-6525 GA Nijmegen, Netherlands
[5] La Jolla Inst Allergy & Immunol, Div Cell Biol, La Jolla, CA 92037 USA
[6] RIKEN Ctr Integrat Med Sci IMS RCAI, Lab Allerg Dis, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan
基金
美国国家卫生研究院;
关键词
FC-EPSILON-RI; REAL-TIME ANALYSIS; DC-SIGN; IMMUNOLOGICAL SYNAPSE; ADAPTIVE IMMUNITY; IN-VIVO; EXPRESSION; RECEPTOR; MATURATION; RESPONSES;
D O I
10.1083/jcb.201412074
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Mast cells (MCs) produce soluble mediators such as histamine and prostaglandins that are known to influence dendritic cell (DC) function by stimulating maturation and antigen processing. Whether direct cell-cell interactions are important in modulating MC/DC function is unclear. In this paper, we show that direct contact between MCs and DCs occurs and plays an important role in modulating the immune response. Activation of MCs through FceRI cross-linking triggers the formation of stable cell-cell interactions with immature DCs that are reminiscent of the immunological synapse. Direct cellular contact differentially regulates the secreted cytokine profile, indicating that MC modulation of DC populations is influenced by the nature of their interaction. Synapse formation requires integrin engagement and facilitates the transfer of internalized MC-specific antigen from MCs to DCs. The transferred material is ultimately processed and presented by DCs and can activate T cells. The physiological outcomes of the MC-DC synapse suggest a new role for intercellular crosstalk in defining the immune response.
引用
收藏
页码:851 / 864
页数:14
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