Orthobiologics for Bone Healing

被引：49

作者：

Calcei, Jacob G. ^{[1
]}

Rodeo, Scott A. ^{[1
]}

机构：

[1] Hosp Special Surg, Dept Sports Med & Shoulder, 535 E 70th St, New York, NY 10021 USA

来源：

CLINICS IN SPORTS MEDICINE | 2019年 / 38卷 / 01期

关键词：

Orthobiologics; Bone healing; Fracture healing; Tendon-to-bone; Bone grafting; Nonunion; ANTERIOR CRUCIATE LIGAMENT; PARATHYROID-HORMONE; 1-34; PLATELET-RICH PLASMA; ROTATOR CUFF REPAIR; GROWTH-FACTOR-BB; CIGARETTE-SMOKING; VITAMIN-D; POSTMENOPAUSAL WOMEN; ILIAC CREST; RHPDGF-BB;

D O I：

10.1016/j.csm.2018.08.005

中图分类号：

G8 [体育];

学科分类号：

04 ; 0403 ;

摘要：

Orthobiologics are a group of biological materials and substrates that promote bone, ligament, muscle, and tendon healing. These substances include bone autograft, bone allograft, demineralized bone matrix, bone graft substitutes, bone marrow aspirate concentrate, platelet-rich plasma, bone morphogenetic proteins, platelet-derived growth factor, parathyroid hormone, and vitamin D and calcium. Properties of orthobiologics in bone healing include osteoconduction, osteoinduction, and osteogenesis. This article discusses the important properties of orthobiologics in bone healing, many of the orthobiologics currently available for bone healing, the related literature, their current clinical uses in sports medicine, and systemic factors that inhibit bone healing.

引用

页码：79 / +

页数：18

共 97 条

[1] Cigarette smoking and open tibial fractures [J].

Adams, CI ;

Keating, JF ;

Court-Brown, CM .

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 2001, 32 (01) :61-65

[2] Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34) [J].

Alkhiary, YM ;

Gerstenfeld, LC ;

Krall, E ;

Westmore, M ;

Sato, M ;

Mitlak, BH ;

Einhorn, TA .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2005, 87A (04) :731-741

[3] Short-term effects of teriparatide versus placebo on bone biomarkers, structure, and fracture healing in women with lower-extremity stress fractures: A pilot study [J].

Almirol, Ellen A. ;

Chi, Lisa Y. ;

Khurana, Bharti ;

Hurwitz, Shelley ;

Bluman, Eric M. ;

Chiodo, Christopher ;

Matzkin, Elizabeth ;

Baima, Jennifer ;

LeBoff, Meryl S. .

JOURNAL OF CLINICAL AND TRANSLATIONAL ENDOCRINOLOGY, 2016, 5 :7-14

[4] Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures [J].

Andreassen, TT ;

Ejersted, C ;

Oxlund, H .

JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (06) :960-968

[5] Effect of Diet-Induced Vitamin D Deficiency on Rotator Cuff Healing in a Rat Model [J].

Angeline, Michael E. ;

Ma, Richard ;

Pascual-Garrido, Cecilia ;

Voigt, Clifford ;

Deng, Xiang Hua ;

Warren, Russell F. ;

Rodeo, Scott A. .

AMERICAN JOURNAL OF SPORTS MEDICINE, 2014, 42 (01) :27-34

[6] Teriparatide for Acceleration of Fracture Repair in Humans: A Prospective, Randomized, Double-Blind Study of 102 Postmenopausal Women With Distal Radial Fractures [J].

Aspenberg, Per ;

Genant, Harry K. ;

Johansson, Torsten ;

Nino, Antonio J. ;

See, Kyoungah ;

Krohn, Kelly ;

Garcia-Hernandez, Pedro A. ;

Recknor, Christopher P. ;

Einhorn, Thomas A. ;

Dalsky, Gail P. ;

Mitlak, Bruce H. ;

Fierlinger, Anke ;

Lakshmanan, Mark C. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2010, 25 (02) :404-414

[7] Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men [J].

Avenell, Alison ;

Mak, Jenson C. S. ;

O'Connell, Dianne .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2014, (04)

[8] Growth factor regulation of fracture repair [J].

Barnes, GL ;

Kostenuik, PJ ;

Gerstenfeld, LC ;

Einhorn, TA .

JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (11) :1805-1815

[9] Diabetes mellitus impairs tendon-bone healing after rotator cuff repair [J].

Bedi, Asheesh ;

Fox, Alice J. S. ;

Harris, Paul E. ;

Deng, Xiang-Hua ;

Ying, Liang ;

Warren, Russell F. ;

Rodeo, Scott A. .

JOURNAL OF SHOULDER AND ELBOW SURGERY, 2010, 19 (07) :978-988

[10] Cigarette smoking and its impact on fracture healing [J].

Bender, Daniel ;

Jefferson-Keil, Tamara ;

Biglari, Bahram ;

Swing, Tyler ;

Schmidmaier, Gerhard ;

Moghaddam, Arash .

TRAUMA-ENGLAND, 2014, 16 (01) :18-22

← 1 2 3 4 5 6 7 8 9 10 →