Striatoids A-F, Cyathane Diterpenoids with Neurotrophic Activity from Cultures of the Fungus Cyathus striatus

被引：63

作者：

Bai, Rui ^{[1
]}

Zhang, Cheng-Chen ^{[1
]}

Yin, Xia ^{[1
]}

Wei, Jing ^{[1
]}

Gao, Jin-Ming ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Sci, Shaanxi Key Lab Nat Prod & Chem Biol, Yangling 712100, Shaanxi, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2015年 / 78卷 / 04期

关键词：

NERVE GROWTH-FACTOR; MUSHROOM SARCODON-SCABROSUS; INDUCED NEURITE OUTGROWTH; HERICIUM-ERINACEUM; PC12; CELLS; FACTOR (NGF)-SYNTHESIS; BITTER MUSHROOM; MYCELIA; BASIDIOMYCETE; STIMULATORS;

D O I：

10.1021/np501030r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new highly oxygenated polycyclic cyathane-xylosides, named striatoids A-F (1-6), were isolated from the cultures of the basidiomycete Cyathus striatus. Their structures were established by comprehensive spectroscopic analysis including 2D NMR (HMBC, HSQC, ROESY, H-1-H-1-COSY) and HRESIMS experiments. Compounds 2 and 3 possess an unusual 15,4'-ether ring system. The isolated compounds dose-dependently enhanced nerve growth factor (NGF)-mediated neurite outgrowth in rat pheochromocytoma (PC-12) cells.

引用

页码：783 / 788

页数：6

共 29 条

[1] CYATHIN - NEW ANTIBIOTIC COMPLEX PRODUCED BY CYATHUS-HELENAE [J].