The impact of corticosteroids on the developing animal

被引:47
作者
Edwards, HE
Burnham, WM
机构
[1] Univ Toronto, Fac Med, Dept Pharmacol, Toronto, ON M5S 1A8, Canada
[2] Univ Toronto, Fac Med, Bloorview Epilepsy Res Program, Toronto, ON, Canada
关键词
D O I
10.1203/00006450-200110000-00003
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Infants are subjected to both endogenous and exogenous corticosteroids in the pre- and postnatal periods. Stress to the mother before birth, or to the child postpartum, can give rise to high, chronic endogenous corticosteroid levels caused by activation of the hypothalamic-pituitary-adrenal (HPA) axis. Physician-administered exogenous corticosteroids are also used in the management of a wide spectrum of pre- and postnatal conditions. The long-term effects of corticosteroids in developing humans are not well known. Studies in animals, however, indicate that both natural stress and exogenous corticosteroids can have longlasting and deleterious effects on the body, brain, behavior, and hypothalamic-pituitary-adrenal axis of developing infants. These data suggest that exogenous corticosteroids should be administered with caution, after careful benefit/risk analyses, and that, as far as possible, the developing brain should be protected against the effects of pre- and postnatal stress.
引用
收藏
页码:433 / 440
页数:8
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