Secreted Factors from Bifidobacterium animalis subsp lactis Inhibit NF-κB-Mediated Interleukin-8 Gene Expression in Caco-2 Cells

被引：19
|
作者：
Wang, Zhonggui [2 ]
Wang, Jinfeng [2 ]
Cheng, Yi [3 ]
Liu, Xin [1 ]
Huang, Ying [2 ]
机构：
[1] Jilin Univ, China Japan Union Hosp, Changchun 130031, Peoples R China
[2] Jilin Univ, Dept Biochem & Mol Biol, Clin Hosp 2, Changchun 130041, Peoples R China
[3] Jilin Univ, Clin Hosp 1, Changchun 130021, Peoples R China
来源：
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2011年 / 77卷 / 22期
关键词：
INTESTINAL EPITHELIAL-CELLS; GUT; BACTERIA; INFLAMMATION; MICROFLORA; COLITIS; COLON;
D O I：
10.1128/AEM.06145-11
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The objective of the present study was to evaluate the anti-inflammatory effects of Bifidobacterium animalis subsp. lactis strain BB12 in stimulated Caco-2 cells and to characterize the factors responsible for these anti-inflammatory effects. Characterization and purification studies indicate that BB12's anti-inflammatory factors might include a 50-kDa proteinaceous compound that is stable under a variety of heat and pH conditions.
引用
收藏
页码：8171 / 8174
页数：4
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