Synthesis and antimicrobial activity of some 5-aryl-2-[(N,N-disubstituted thiocarbamoylthio)acylamino]-1,3,4-oxadiazoles

被引:30
作者
Ates, Ö [1 ]
Kocabalkanli, A
Cesur, N
Ötük, G
机构
[1] Univ Istanbul, Fac Pharm, Dept Pharmaceut Chem, TR-34452 Istanbul, Turkey
[2] Univ Istanbul, Fac Pharm, Dept Microbiol, TR-34452 Istanbul, Turkey
来源
FARMACO | 1998年 / 53卷 / 8-9期
关键词
antibacterial drugs; 5-aryl-2-[(N,N-disubstituted thiocarbamoylthio)acylamino]-1,3,4-oxadiazole microbiology; synthesis;
D O I
10.1016/S0014-827X(98)00063-9
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In this study, a number of novel 5-aryl-2-[(N,N-disubstituted thiocarbamoylthio)acylamino]-1,3,4-oxadiazole derivatives were synthesized by the reaction of potassium salts of N,N-disubstituted dithiocarbamoic acids with 2-[(alpha-chloro-alpha-phenylacetyl/alpha-bromopropionyl)-amino]-5-aryl-1,3,4-oxadiazoles. Structures of the compounds were confirmed by the spectral data (IR, H-1 NMR, EIMS) and elemental analyses. Most of the compounds were tested against various microorganisms and four of them were found to be weakly active against Staphylococcus aureus and Staphylococcus epidermidis. (C) 1998 Elsevier Science S.A. All rights reserved.
引用
收藏
页码:541 / 544
页数:4
相关论文
共 13 条
  • [1] Ates O, 1997, ARZNEIMITTEL-FORSCH, V47, P1134
  • [2] ATES O, 1995, FARMACO, V50, P361
  • [3] BANSAL RK, 1982, J INDIAN CHEM SOC, V59, P277
  • [4] CAPAN G, 1993, SCI PHARM, V61, P243
  • [5] CESUR N, 1994, ACTA PHARM TURC, V36, P74
  • [6] FUCHSMANN CH, 1971, Patent No. 3557174
  • [7] Synthesis and antifungal activity of new carbamodithioic acid esters derived from 3-acetylcoumarin
    Gursoy, A
    Ates, O
    Karali, N
    Cesur, N
    Kiraz, M
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1996, 31 (7-8) : 643 - 646
  • [8] KACHROO PL, 1991, NAT ACAD SCI LETT, V13, P125
  • [9] SAIKAWA I, 1962, Patent No. 11384
  • [10] SCHONENBERGER H, 1972, PHARMAZIE, V27, P139